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Proteases/Proteasome Cysteine Protease ML224

ML224

Catalog No. T16106   CAS 1338824-21-7
Synonyms: NCGC00242364, ANTAG3

ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).

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ML224, CAS 1338824-21-7
Pack Size Availability Price/USD Quantity
2 mg Inquiry 88.00
5 mg Inquiry 126.00
10 mg Inquiry 198.00
50 mg Inquiry 612.00
100 mg Inquiry 976.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
Targets&IC50 Others
In vivo ANTAG3 lowered serum-free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively, in mice treated with TRH. ANTAG3 lowered serum-free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively, in mice given M22 [2].
Synonyms NCGC00242364 , ANTAG3
Purity
Molecular Weight 525.59
Formula C31H31N3O5
CAS No. 1338824-21-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 100 mg/mL (190.26 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program 2. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

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