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ML224

Catalog No. T16106 CAS 1338824-21-7

Synonyms: NCGC00242364, ANTAG3

ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).

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ML224, CAS 1338824-21-7

Pack Size	Availability	Price/USD
2 mg	Inquiry	88.00
5 mg	Inquiry	126.00
10 mg	Inquiry	198.00
50 mg	Inquiry	612.00
100 mg	Inquiry	976.00

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Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
Targets&IC50	Others
In vivo	ANTAG3 lowered serum-free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively, in mice treated with TRH. ANTAG3 lowered serum-free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively, in mice given M22 [2].

Synonyms	NCGC00242364 , ANTAG3
Purity
Molecular Weight	525.59
Formula	C31H31N3O5
CAS No.	1338824-21-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 100 mg/mL (190.26 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program 2. Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

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