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Search Results for " trxr1 "

Targets

8

Compounds

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T29017 TrxR1-IN-B19 TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015 Others
TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
T78781 TrxR1-IN-1
Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and ...
T4414 Eprenetapopt APR-246,PRIMA-1Met Apoptosis , Others , Ferroptosis , p53 , Autophagy
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...
T39664 Ethaselen BBSKE
Ethaselen (BBSKE), a selective thioredoxin reductase (TrxR) inhibitor, is orally active with IC50s of 0.5 and 0.35 μM for wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique sele...
T11130 DVD-445 Others
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M.
T14351 Aurothioglucose Gold thioglucose Others
Aurothioglucose is a active-site TrxR1 inhibitor.
T73512 ZC0109
ZC0109, a dual inhibitor targeting IDO1 and Thioredoxin Reductase 1 (TrxR1) with IC50 values of 50 nM and 3.0 μM respectively, effectively promotes ROS accumulation and arrests the cell cycle at the G1/S phase, culminati...
T73547 CPUL1
CPUL1, a TrxR inhibitor, exhibits proliferation-inhibitory and anti-metastatic effects on A549 cells by modulating epithelial-mesenchymal transition (EMT) through the induction of ROS-mediated ERK/JNK signaling, achieved...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02271 TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) Human E. coli
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat...
TargetMol