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Search Results for " trpm8 "

20

Compounds

Cat No. Product Name Synonyms Targets
T5698 TRPM8 antagonist 2 TRP/TRPV Channel
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.
T9709 TRPM8 antagonist 3 TRP/TRPV Channel
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).
T5962 TRPM8 antagonist WS-3 Cyclohexanecarboxamide,N-Ethyl-p-menthane-3-carboxamide,N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide TRP/TRPV Channel
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
T2007 RQ-00203078 TRP/TRPV Channel
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T19723 AMTB hydrochloride AMTB TRP/TRPV Channel
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...
T16483 PF-05105679 TRP/TRPV Channel
PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.
T1814 ICILIN AG-3-5 TRP/TRPV Channel
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
T5479 AMG 333 AMG-333 TRP/TRPV Channel
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T7416 WS-12 TRP/TRPV Channel
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
T8449 TC-I2000 TRP/TRPV Channel
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
T10300 AMG2850 TRP/TRPV Channel
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T8442 M8-B Hydrochloride TRP/TRPV Channel
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
T27308 FEMA-4809 FEMA4809,FEMA 4809 TRP/TRPV Channel
FEMA-4809, a highly potent TRPM8 receptor activator, TRPM8 is the ion channel responsible for the cool perception, which is triggered either by temperatures below 25 °C or by ligands such as (-)-menthol. FEMA-4809 is use...
T10929L D-3263 hydrochloride EC D-3263 HCl,D3263 HCl salt TRP/TRPV Channel
D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
T16763 RN-1747 TRP/TRPV Channel
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively). RN-1747 also antagonizes TRPM8 (IC50: 4 μM...
TQ0001 1,4-Cineole Isocineole Endogenous Metabolite , TRP/TRPV Channel
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T16532 Pico145 HC-608 TRP/TRPV Channel
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, T...
T1407 (-)-Menthol L-Menthol,Levomenthol,Menthomenthol,Menthacamphor Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo...
T7102 BCTC TRP/TRPV Channel
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T17006 TC-I 2014 TRP/TRPV Channel
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine,...
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