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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5698 | TRPM8 antagonist 2 | TRP/TRPV Channel | |
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. | |||
T9709 | TRPM8 antagonist 3 | TRP/TRPV Channel | |
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM). | |||
T5962 | TRPM8 antagonist WS-3 | Cyclohexanecarboxamide,N-Ethyl-p-menthane-3-carboxamide,N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide | TRP/TRPV Channel |
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM). | |||
T2007 | RQ-00203078 | TRP/TRPV Channel | |
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. | |||
T19723 | AMTB hydrochloride | AMTB | TRP/TRPV Channel |
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl... | |||
T16483 | PF-05105679 | TRP/TRPV Channel | |
PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain. | |||
T1814 | ICILIN | AG-3-5 | TRP/TRPV Channel |
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. | |||
T5479 | AMG 333 | AMG-333 | TRP/TRPV Channel |
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine. | |||
T7416 | WS-12 | TRP/TRPV Channel | |
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM) | |||
T8449 | TC-I2000 | TRP/TRPV Channel | |
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM. | |||
T10300 | AMG2850 | TRP/TRPV Channel | |
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8). | |||
T8442 | M8-B Hydrochloride | TRP/TRPV Channel | |
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist. | |||
T27308 | FEMA-4809 | FEMA4809,FEMA 4809 | TRP/TRPV Channel |
FEMA-4809, a highly potent TRPM8 receptor activator, TRPM8 is the ion channel responsible for the cool perception, which is triggered either by temperatures below 25 °C or by ligands such as (-)-menthol. FEMA-4809 is use... | |||
T10929L | D-3263 hydrochloride | EC D-3263 HCl,D3263 HCl salt | TRP/TRPV Channel |
D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist. | |||
T16763 | RN-1747 | TRP/TRPV Channel | |
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively). RN-1747 also antagonizes TRPM8 (IC50: 4 μM... | |||
TQ0001 | 1,4-Cineole | Isocineole | Endogenous Metabolite , TRP/TRPV Channel |
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. | |||
T16532 | Pico145 | HC-608 | TRP/TRPV Channel |
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, T... | |||
T1407 | (-)-Menthol | L-Menthol,Levomenthol,Menthomenthol,Menthacamphor | Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel |
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo... | |||
T7102 | BCTC | TRP/TRPV Channel | |
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively) | |||
T17006 | TC-I 2014 | TRP/TRPV Channel | |
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine,... |