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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9921 | Infliximab | TNF | |
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. | |||
T61111 | UCB-5307 | TNF | |
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas... | |||
T38361 | GSK717 | IL Receptor , NOD | |
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... | |||
T71807 | UCB-6786 | ||
UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein... | |||
T68954 | UCB-6876 | ||
UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control protein... | |||
T80561 | Atrosab | ||
Atrosab, a humanized IgG1 anti-TNFR1 antibody, exhibits antagonistic properties by inhibiting TNF-induced apoptosis and reducing the production of IL-6 and IL-8. It is utilized for research on inflammatory diseases [1]. | |||
T27687 | JNJ525 | JNJ 525,JNJ-525 | |
JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of co... | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in... | |||
T36486 | Benpyrine | ||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten... | |||
T38263 | TBK1/IKKε-IN-4 | TBK1/IKKε-IN-4 | |
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ... |