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Cat No. | Product Name | Synonyms | Targets |
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T13138 | TGFBR1-IN-1 | ALK | |
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM). | |||
T35896 | AZ 12799734 | AZ12799734 | ALK |
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours. | |||
T6496 | Vactosertib | TEW-7197,EW-7197 | ALK , TGF-beta/Smad |
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... | |||
T10426 | AZ12601011 | ALK | |
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively in... | |||
T83770 | Klotho-derived Peptide 1 (56-87) (human) TFA | KP1 (56-87) | |
Klotho-derived peptide 1 (KP1) (56-87), a peptide originating from the human Klotho protein, disrupts TGF-β signaling by binding to TGF-β receptor types 1 and 2 (TGFBR1 and TGFBR2; Kds = 1.41 and 14.6 µM, respectively). ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00305 | TGFBR1 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPJ-01178 | TGFBR1 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho... | |||
TMPK-00306 | TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPY-01358 | ALK-5 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si... | |||
TMPH-02968 | VEPH1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and W... | |||
TMPY-04366 | ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) | Human | Baculovirus-Insect Cells |
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si... | |||
TMPY-05771 | ALK-5 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si... | |||
TMPJ-00361 | Endoglin Protein, Human, Recombinant (Trx & His) | Human | E. coli |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a... | |||
TMPH-01261 | NEDD4L Protein, Human, Recombinant (GST) | Human | E. coli |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig... | |||
TMPH-00306 | TGF-beta 2 Protein, Bovine, Recombinant (His & Myc) | Bovine | E. coli |
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2,... | |||
TMPH-00382 | TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO) | Chicken | E. coli |
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,... | |||
TMPH-00305 | TGF-beta 1 Protein, Bovine, Recombinant (His) | Bovine | E. coli |
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,... |