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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0760 | Cholesterol | Cholesterin,Cholesteryl alcohol | Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR |
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us... | |||
TN6751 | 1-HEXACOSANOL | NPC1L1 , AMPK | |
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. | |||
T77289 | 5-O-Methylembelin | ||
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9 , low-density lipoprotein receptor (IDOL) , and sterol regulatory element binding protein 2 (SREBP2) mRNA expression [1] . | |||
T75545 | PCSK9-IN-9 | ||
PCSK9-IN-9, a natural isocoumarin, inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression, demonstrating specificity by inhibiting PCSK9 with an IC50 value of 11.9 μM [1]. |