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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9568 | SGC-SMARCA-BRDVIII | Epigenetic Reader Domain | |
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively. | |||
T17350 | ACBI1 | Apoptosis , Epigenetic Reader Domain , PROTACs | |
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ... | |||
T6939 | PFI-3 | PFI 3 | Epigenetic Reader Domain |
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer. | |||
T81147 | SMD-3040 TFA | Ligands for Target Protein for PROTAC | |
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis. It demonstrates robust tumor growth inhibition in tumor xenograft models [1]. | |||
T79820 | SMD-3040 | Epigenetic Reader Domain | |
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the ... | |||
T81376 | PROTAC SMARCA2 degrader-2 | PROTACs | |
PROTAC SMARCA2 degrader-2, a selective and powerful degrader of SMARCA2/4, exhibits an IC50 of <0.1 μΜ in the HeLa HiBiT assay.this compound holds promise for research into cancers related to or deficient in SMARCA4 [1]. |