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Search Results for " smarca2/4 "

6

Compounds

Cat No. Product Name Synonyms Targets
T9568 SGC-SMARCA-BRDVIII Epigenetic Reader Domain
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
T17350 ACBI1 Apoptosis , Epigenetic Reader Domain , PROTACs
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ...
T6939 PFI-3 PFI 3 Epigenetic Reader Domain
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
T81147 SMD-3040 TFA Ligands for Target Protein for PROTAC
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis. It demonstrates robust tumor growth inhibition in tumor xenograft models [1].
T79820 SMD-3040 Epigenetic Reader Domain
SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), which consists of an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the ...
T81376 PROTAC SMARCA2 degrader-2 PROTACs
PROTAC SMARCA2 degrader-2, a selective and powerful degrader of SMARCA2/4, exhibits an IC50 of <0.1 μΜ in the HeLa HiBiT assay.this compound holds promise for research into cancers related to or deficient in SMARCA4 [1].
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