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Search Result

Search Results for " sirt6 "

10

Compounds

Cat No. Product Name Synonyms Targets
T24793 SIRT6-IN-5 SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 Sirtuin
SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ...
T4328 OSS_128167 SIRT6-IN-1 HBV , Sirtuin
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T28784 SIRT6-IN-1
SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.
T72484 SIRT6 activator 12q
SIRT6 activator 12q is a potent, selective, and orally active compound that activates SIRT6. It demonstrates IC50 values of 171.20 μM for SIRT1, >200 μM for SIRT2, SIRT3, and SIRT5, and 0.58 μM for SIRT6, indicating its ...
T79689 SIRT6-IN-3 Sirtuin
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ...
T7679 UBCS039 Sirtuin , Autophagy
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T64529 MDL-800 MDL 800,MDL800 Sirtuin
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
T69707 MDL-801
MDL-801 is an activator of SIRT6 deacetylation.
T75107 CrBKA
CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .
T81831 MDL-811 Sirtuin
MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac), presenting potential utility in colorectal cancer research [1]...
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