Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
2 mg | In stock | $ 96.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 472.00 | |
50 mg | In stock | $ 689.00 | |
100 mg | In stock | $ 983.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 170.00 |
Description | UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) |
Targets&IC50 | SIRT6:38 μM |
In vitro | UBCS039 induced a time-dependent activation of autophagy in several human tumor cell lines, as evaluated by increased content of the lipidated form of LC3B by western blot and of autophagosomal puncta by microscopy analysis of GFP-LC3.?UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy.?At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.?Interestingly, antioxidants were able to completely counteract UBCS039-induced autophagy, suggesting that ROS burst had a key role in upstream events leading to autophagy commitment. |
Molecular Weight | 247.29 |
Formula | C16H13N3 |
CAS No. | 358721-70-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (505.48 mM)
You can also refer to dose conversion for different animals. More
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UBCS039 358721-70-7 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin UBCS 039 UBCS-039 inhibit Inhibitor inhibitor