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Search Result

Search Results for " shp1 "

Targets

Phosphatase

13

Compounds

1

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T28410 PHPS1 PHPS-1,PHPS 1 Phosphatase
PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
T16350 NSC-87877 Apoptosis , Phosphatase
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
T4627 SPI--112Me Others
SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays.
T73552 BPDA2
BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively. This compound effectively downregulates mitogenic and ce...
T6911 NSC-87877 disodium NSC87877 Apoptosis , Phosphatase
NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduce...
T3962 TPI-1 TPI 1,TPI1 Phosphatase , Glucocorticoid Receptor
TPI-1 is a SHP-1 inhibitor.
T25953 PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt
PHPS1 sodium is a potent and selective inhibitor of Shp2, with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively [1].
T7541 PTP inhibitor 1 PTP Inhibitor II Phosphatase
PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.
T39167 GS-493
GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counter...
T7084 2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide Phosphatase
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH...
T61701 SHP2-IN-9
SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. ...
T38834 LYP-IN-1
LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wid...
T35940 Darinaparsin Dimethylarsinic glutathione,Darinaparsin
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M)...
Cat No. Product Name Synonyms Targets
T79985 Cryptosporioptide A Phosphatase
Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound effectively inhibits several enzymes including PTP1B, SHP2, CD...

Natural Products

Cryptosporioptide A
T79985
Synonym:
Target: Phosphatase

Recombinant Proteins

Species：
Mouse (3)
Human (1)
Expression System：
HEK293 (2)
Baculovirus-Insect Cells (1)
Human Cells (1)
Tag：
C-Fc-6His (1)
His (1)
His,GST (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-02632 SIRP alpha Protein, Mouse, Recombinant (His) Mouse HEK293
Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antig...
TMPY-02636 SIRP alpha Protein, Mouse, Recombinant (hFc) Mouse HEK293
Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antig...
TMPY-03296 SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) Mouse Baculovirus-Insect Cells
PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and onco...
TMPJ-00537 Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) Human Human Cells
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytopla...
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