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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2074 | Raf inhibitor 1 | B-Raf inhibitor 1 | Raf |
B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor. | |||
T4167 | Raf inhibitor 1 dihydrochloride | B-Raf inhibitor 1 dihydrochloride | Raf |
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor. | |||
T4194 | Raf inhibitor 2 | CID-25014542,CID 25014542,CID25014542 | Raf |
Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases. | |||
T1845 | B-Raf IN 1 | Raf | |
B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor. | |||
T40284 | B-Raf IN 2 | Raf | |
B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research. | |||
T19802 | B-Raf IN 11 | Raf | |
B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer. | |||
T63644 | Exarafenib | RAF/KIN_2787 | Raf , p38 MAPK |
Exarafenib (RAF/KIN_2787) is a potent and orally available pan-RAF inhibitor.Exarafenib has antitumor activity and acts by inhibiting downstream MAPK pathway signaling.Exarafenib is used in cancer research. | |||
T78183 | B-Raf IN 15 | Raf | |
B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used in the study of melanoma and cancer, and can be optimized for use as a more effective BRA F inhibitor. | |||
T63333 | Uplarafenib | B-Raf IN 10 | Raf |
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study soli... | |||
T79830 | B-Raf IN 16 | Raf | |
B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research. | |||
T72070 | B-Raf IN 14 | Bradykinin Receptor | |
B-Raf IN 14 is a BRAF inhibitor. | |||
T36642 | RAS/RAS-RAF-IN-1 | ||
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for ... | |||
T12685 | RAF mutant-IN-1 | Others | |
RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively). | |||
T67862 | B-Raf IN 13 | Raf | |
B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay. | |||
T12556 | PROTAC B-Raf degrader 1 | Raf | |
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity. | |||
T3711 | RAF709 | Raf | |
RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively. | |||
T63365 | RAF-IN-1 | ||
RAF-IN-1 is a potent inhibitor of b/cRAF, acting on cRAF (IC50: 3.8 nM), bRAFwt (IC50: 36 nM), bRAFV600E (IC50: 29.4 nM) and inhibiting A375 and H358 cell lines carrying the bRAFV600E mutation with a GI50 of 3.4 and 2.9 ... | |||
T79813 | Raf inhibitor 3 | Raf | |
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1]. | |||
T64116 | B-Raf IN 5 | ||
B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR. | |||
T60727 | B-Raf IN 8 | ||
B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which has IC 50 values of 9.78, 13.78, 18.52 and 29.85 μM against hepatocellular carcinoma (HEPG-2), colon ... |