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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4687 | Ro5-3335 | CBFβ-Runx1 inhibitor II,Ro 5-3335 | DNA/RNA Synthesis |
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ... | |||
T61098 | RUNX1/ETO tetramerization-IN-1 | ||
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully rest... | |||
T28578 | Ro24-7429 | Ro 24-7429,Ro-24-7429,Ro 247429 | HIV Protease |
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects. | |||
T22195 | CBFβ Inhibitor | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | DNA/RNA Synthesis |
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1. | |||
T6753 | AI-10-49 | DNA/RNA Synthesis | |
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. | |||
T1748 | Kartogenin | KGN | TGF-beta/Smad |
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | |||
T24550 | NSC-140873 | GCPK | |
NSC-140873 is the RUNX1-CBFβ interaction inhibitor. | |||
T26580 | AI-4-57 Hydrochloride | AI457 HCl,AI-4-57 HCl,AI 4 57 HCl | |
AI-4-57 Hydrochloride is a ligand to the CBFß. AI-4-57 Hydrochloride is a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain. | |||
T69678 | WUN40378 | ||
WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of... |