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Search Results for " runx1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T4687 Ro5-3335 CBFβ-Runx1 inhibitor II,Ro 5-3335 DNA/RNA Synthesis
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ...
T61098 RUNX1/ETO tetramerization-IN-1
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully rest...
T28578 Ro24-7429 Ro 24-7429,Ro-24-7429,Ro 247429 HIV Protease
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.
T22195 CBFβ Inhibitor 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine DNA/RNA Synthesis
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
T6753 AI-10-49 DNA/RNA Synthesis
AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
T1748 Kartogenin KGN TGF-beta/Smad
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T24550 NSC-140873 GCPK
NSC-140873 is the RUNX1-CBFβ interaction inhibitor.
T26580 AI-4-57 Hydrochloride AI457 HCl,AI-4-57 HCl,AI 4 57 HCl
AI-4-57 Hydrochloride is a ligand to the CBFß. AI-4-57 Hydrochloride is a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain.
T69678 WUN40378
WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of...
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