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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP2127 | R18 | ||
Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzy... | |||
T75776 | R18 TFA | ||
R18 TFA, a peptide antagonist of 14-3-3, exhibits a dissociation constant (K_D) of 70-90 nM. It efficiently inhibits the interaction between 14-3-3 and its physiological ligand, the kinase Raf-1, thereby significantly im... | |||
T9975 | GPR183 | 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide | Others |
GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes... | |||
T7156 | NIBR189 | EBI2/GPR183 | |
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively) | |||
T28856 | SSR180711 hydrochloride | SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl | AChR |
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders. | |||
T11319 | FR183998 free base | Na+/Ca2+ Exchanger | |
FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger. | |||
T22429 | SR18662 | DNA/RNA Synthesis | |
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis. | |||
T16900 | SMER18 | Others | |
SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer. |