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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9229 | Pim-1/2 kinase inhibitor 1 | Pim | |
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... | |||
T3058 | (Z)-SMI-4a | TCS PIM-1 4a,SMI-4a | Pim |
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. | |||
T23158 | PIM-1 Inhibitor 2 | Others | |
PIM-1 Inhibitor 2 is an effective Pim-1 kinase inhibitor (Ki = 91 nM). | |||
T3989 | SMI-16a | PIM1/2 Kinase Inhibitor VI | Pim |
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against... | |||
T2253 | TCS PIM-1 1 | SC 204330 | Pim |
TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM). | |||
T81460 | PIM-IN-2 | Pim | |
PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM . It exhibits antiapoptotic properties conducive to cell survival and has been found to ... | |||
T62001 | Pim-1 kinase inhibitor 2 | ||
Pim-1 kinase inhibitor 2 (Compound 13), a potent inhibitor of Pim-1 kinase, has the potential for cancer research due to its ability to induce apoptosis [1]. | |||
T15830 | M-110 | Pim | |
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate ca... | |||
T6148 | CX-6258 hydrochloride | CX-6258 HCl,Pim-Kinase Inhibitor X | Pim |
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM). | |||
T1834 | CX-6258 | CX 6258 | Pim |
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity. | |||
T3078 | SGI-1776 | SGI-1776 free base,Pim-Kinase Inhibitor IX | Apoptosis , FLT , Pim , Autophagy |
SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias. | |||
T9583 | HJ-PI01 | N-Acetylphenoxazine,10-acetylphenoxazine | Pim |
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer. | |||
T63589 | CX-6258 hydrochloride hydrate | ||
CX-6258 hydrochloride hydrate is a potent and selective inhibitor of pan-Pim kinase that acts on Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM) and Pim-3 (IC50: 16 nM). | |||
T68341 | HS56 | ||
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor, displaying K i values of 0.26 μM for DAPK3, 0.208 μM for Pim-3, 2.94 μM for Pim-1, and >100 μM for Pim-2. This compound effectively inhibits LC20 phosphorylation and s... | |||
T39085 | SEL24-B489 | SEL24-B489 | |
SEL24-B489 is a highly effective and orally bioavailable compound that acts as a robust, type I inhibitor of both PIM and FLT3-ITD. It exhibits exceptional binding affinity with K d values of 2 nM for PIM1, 2 nM for PIM2... |