Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 548.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM. |
In vitro | M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM. M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50 values of 0.6 to 0.8 μM. M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells (IC50: 0.9 μM). M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705 phosphorylation[1]. |
Molecular Weight | 445.94 |
Formula | C22H28ClN5O3 |
CAS No. | 1395048-49-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.5mg/mL (70.6mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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M-110 1395048-49-3 Chromatin/Epigenetic JAK/STAT signaling Pim M110 M 110 inhibitor inhibit