ptp1b — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7356	PTP1B-IN-1	PTP1B inhibitor	Phosphatase
	PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)		Phosphatase
T12577	PTP1B-IN-3		Phosphatase
	PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.		Phosphatase
T67893	PTP1B-IN-22		Phosphatase
	PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.		Phosphatase
T4256	PTP1B-IN-2		Phosphatase
	PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).		Phosphatase
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T40745	PTP1B-IN-13	PTP1B-IN-13
	PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.
T40835	PTP1B-IN-14	PTP1B-IN-14
	PTP1B-IN-14 is a selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) that targets the allosteric site, exhibiting an inhibitory concentration (IC50) value of 0.72 μM.
T24073	PTP1B-IN-4	NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724	Phosphatase
	PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.		Phosphatase
T12578	(E,E)-RAMB4	PTP1B-IN-8	Phosphatase
	PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).		Phosphatase
T63435	PTP1B-IN-16
	PTP1B-IN-16 is a promising and selective benzimidazole derivative and an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (Ki: 12.6 μM).PTP1B-IN-16 can be used to study type 2 diabetes.
T63023	PTP1B-IN-19
	PTP1B-IN-19 (Compound 43) is a promising selective benzimidazole derivative as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 23.3 μM).PTP1B-IN-17 can be used to study type 2 diabetes.
T73072	PTP1B-IN-20
	PTP1B-IN-20 is a selective PTP1B (protein tyrosine phosphatase 1B) inhibitor, exhibiting an IC50 of 1.05 μM, and demonstrates selectivity over TCPTP (T-cell protein tyrosine phosphatase), which has an IC50 of 78.0 μM. Th...
T63022	PTP1B-IN-18
	PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.
T63021	PTP1B-IN-17
	PTP1B-IN-17 (Compound 45) is a selective benzimidazole derivative with potential as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 30.2 μM).PTP1B-IN-17 can be used in the study of type 2 diabetes.
T63739	PTP1B-IN-15
	PTP1B-IN-15 is a potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor that has shown research potential in type II diabetes and obesity.
T73073	PTP1B-IN-21
	PTP1B-IN-21 is a compound that functions as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM), demonstrating a marked preference over the structurally similar T-cell protein tyrosine phosphat...
T61851	PTP1B-IN-3 diammonium
	PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent an...
T78702	PTP1B/AKR1B1-IN-1		Phosphatase
	PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. Additionally, it...		Phosphatase
T78703	PTP1B/AKR1B1-IN-2		Phosphatase
	PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan...		Phosphatase
T4340	SPI-112		Phosphatase
	SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.		Phosphatase