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Metabolism Phosphatase PTP1B-IN-2

PTP1B-IN-2

Catalog No. T4256   CAS 1919853-46-5

PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).

PTP1B-IN-2, CAS 1919853-46-5
Pack Size Availability Price/USD Quantity
1 mg In stock 108.00
2 mg In stock 195.00
5 mg In stock 365.00
10 mg In stock 560.00
1 mL * 10 mM (in DMSO) In stock 560.00
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Purity 99.58%
Biological Description
Chemical Properties
Storage & Solubility Information
Description PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
Targets&IC50 PTP1B
Kinase Assay The PTP1B enzymatic assay, the total volume of 100 µL per well contains15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37℃, end the reaction by addition of 2.5 M NaOH. The hydrolysis product, pNP, is detected at the absorbance at 405 nm.
Molecular Weight 680.79
Formula C34H36N2O9S2
CAS No. 1919853-46-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 100 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
2. Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA[J]. Journal for immunotherapy of cancer. 2020, 8(2).

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Anti-cancer Metabolism Compound Library Phosphatase Inhibitor Library Anti-COVID-19 Compound Library RdRP-Targeted compound library (CADD) X Domain-Targeted compound library (CADD) nsp15-Targeted compound library (CADD) Neurodegenerative disease-related Compound Library Glycometabolism Compound Library

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