Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 522.00 | |
100 mg | In stock | $ 759.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 183.00 |
Description | PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM). |
Targets&IC50 | PTP1B:50 nM |
In vitro | PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM. |
Kinase Assay | The PTP1B enzymatic assay, the total volume of 100 μL per well contains15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37℃, end the reaction by addition of 2.5 M NaOH. The hydrolysis product, pNP, is detected at the absorbance at 405 nm. |
Molecular Weight | 680.79 |
Formula | C34H36N2O9S2 |
CAS No. | 1919853-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
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PTP1B-IN-2 1919853-46-5 Metabolism Phosphatase Inhibitor PTP-1B-IN-2 inhibit PTP1BIN2 PTP1B IN 2 inhibitor