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PTP1B-IN-2

Catalog No. T4256   CAS 1919853-46-5

PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).

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PTP1B-IN-2 Chemical Structure
PTP1B-IN-2, CAS 1919853-46-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
5 mg In stock $ 122.00
10 mg In stock $ 172.00
25 mg In stock $ 347.00
50 mg In stock $ 522.00
100 mg In stock $ 759.00
1 mL * 10 mM (in DMSO) In stock $ 183.00
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Purity: 99.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
Targets&IC50 PTP1B:50 nM
In vitro PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM.
Kinase Assay The PTP1B enzymatic assay, the total volume of 100 μL per well contains15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37℃, end the reaction by addition of 2.5 M NaOH. The hydrolysis product, pNP, is detected at the absorbance at 405 nm.
Molecular Weight 680.79
Formula C34H36N2O9S2
CAS No. 1919853-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL

TargetMolReferences and Literature

1. Liu P, et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33. 2. Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA[J]. Journal for immunotherapy of cancer. 2020, 8(2).

TargetMolCitations

1. Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA. Journal for immunotherapy of cancer. 2020 Nov;8(2):e001037.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library NO PAINS Compound Library Phosphatase Inhibitor Library Glycometabolism Compound Library Anti-Metabolism Disease Compound Library Anti-COVID-19 Compound Library Bioactive Compound Library

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3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid LYP-IN-3 LYP-IN-4 PRL-3 Inhibitor I h-NTPDase-IN-5 h-NTPDase-IN-3 BTdCPU PTP1B-IN-1

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Keywords

PTP1B-IN-2 1919853-46-5 Metabolism Phosphatase Inhibitor PTP-1B-IN-2 inhibit PTP1BIN2 PTP1B IN 2 inhibitor

 

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