Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 970.00 | |
25 mg | In stock | $ 1,460.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes. |
Targets&IC50 | PTP1B:120 nM, TCPTP:120 nM |
In vivo | In NDL2 Ptpn1 transgenic mice, oral administration of PTP1B-IN-3 (compound 3g) at a dose of 30 mg/kg for 21 days significantly delayed the onset of tumor development in NDL2 Ptpn1+/+ mice, extending the median tumor-free days (T50) from 28 days to 75 days [2].In diet-induced obese (DIO) mice, PTP1B-IN-3 (compound 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and excellent elimination half-life (t1/2 of 6 hours)[2]. |
Molecular Weight | 362.06 |
Formula | C12H7BrF2NO3P |
CAS No. | 809272-64-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PTP1B-IN-3 809272-64-8 Metabolism Phosphatase PTP-1B-IN-3 PTP1BIN3 PTP1B IN 3 inhibitor inhibit