pi3kα-in-4 — TargetMol Chemicals

Search Result

Search Results for " pi3kα-in-4 "

Compounds

Cat No.	Product Name	Synonyms	Targets
T35527	PI3Kα-IN-4	PI3Kα-IN-4
	PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].
T35488	(S)-PI3Kα-IN-4	(S)-PI3Kα-IN-4
	(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the...
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T3351	Onatasertib	CC223,CC 223,CC-223	Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR
	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor ce...		Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR