pde10a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28350	PDE10A-IN-8	PDE10A-IN8,PDE10A-IN 8
	PDE10A-IN-8 is a potent inhibitor of PDE10A.
T12150	N-Methylbenzamide		PDE
	N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.		PDE
T8506	THPP-1		PDE
	THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).		PDE
T24656	PQ-10	A844337,PQ 10,A-844337,A 844337	PDE
	PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.		PDE
T1745	Balipodect	TAK063,TAK-063,TAK 063	PDE
	Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.		PDE
T14217	AMG 579	AMG-579	PDE
	AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).		PDE
T16499	Mardepodect	PF-2545920	PDE
	Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodie...		PDE
T6042	[11C]MP 10	Mardepodect,PF-2545920	PDE
	[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.		PDE
T13189	TP-10		PDE
	TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.		PDE
T62356	Mardepodect hydrochloride	PF-2545920 HCl,Mardepodect HCl,MP-10 HCl,PF-02545920 HCl	Apoptosis , PDE
	Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of prot...		Apoptosis , PDE
T28969	THPP-4
	THPP-4 inhibits phosphodiesterase 10A (PDE10A).
T23430	TC-E 5005		Others
	PDE10A inhibitor		Others
T28088	MP-10 succinate	MP10,MP 10
	MP-10 succinate is a potent and specific inhibitor of PDE10A.
T27685	JNJ-42314415	JNJ 42314415,JNJ42314415
	JNJ-42314415 is a potent, specific, and centrally active inhibitor of PDE10A.
T28968	THPP-2
	HPP-2 is a novel phosphodiesterase 10A (PDE10A) inhibitor used to treat schizophrenia.
T70822	Gemlapodect	RO554965
	Gemlapodect (RO554965), a phosphodiesterase 10A (PDE10A) inhibitor, is utilized in schizophrenia research.
T73462	MK-8189
	MK-8189 is a potent, orally active, and selective inhibitor of Phosphodiesterase 10A (PDE10A), exhibiting a K i value of 29 pM. It has potential applications in the research of schizophrenia.
T12119	MT-3014		Others
	MT-3014 is a potent, highly selective and brain-penetrated inhibitor of phosphodiesterase 10A (PDE 10A)(human PDE 10A and bovine PDE 10A with IC50s of 0.062 nM and 0.09 nM , respectively).		Others
T12394	PDE5-IN-2		PDE
	PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)		PDE
T12393	PDE2/PDE10-IN-1		Others
	PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively).		Others