Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,450.00 | |
50 mg | 6-8 weeks | $ 1,890.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively). |
Targets&IC50 | PDE11A (human):6920 nM, PDE4D (human):5890 nM, PDE10A (rat):480 nM, PDE2A (human):29 nM |
In vitro | PDE2/PDE10-IN-1 inhibits PDE2 and PDE10(IC50 of 29 and 480 nM, respectively). PDE2/PDE10-IN-1 is also inactive up to a concentration of 125 μg/mL in a bacterial mutagenicity assay. PDE2/PDE10-IN-1 also inhibits PDE11A and PDE4D with IC50s of 6920 nM and 5890 nM, respectively. In addition PDE2/PDE10-IN-1 does not show significant inhibition of a panel of CYP450 enzymes (CYP1A2, 2C9, 2D6, 2C19, and 3A4). |
In vivo | PDE2/PDE10-IN-1, which is orally bioavailable, occupies PDE2 with an ED50 of 21 mg/kg. |
Molecular Weight | 295.73 |
Formula | C15H10ClN5 |
CAS No. | 1426833-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PDE2/PDE10-IN-1 1426833-08-0 Others PDE2/PDE10 IN 1 PDE-2/PDE10-IN-1 PDE2/PDE10IN1 inhibitor inhibit