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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4354 | KPT9274 | KPT-9274,KPT 9274,PAK4-IN-1 | NAMPT , PAK |
KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule. | |||
T81569 | PAK4-IN-3 | PAK | |
PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also induces concentration-dependent apoptosis in A549 cells an... | |||
T63934 | PAK4-IN-1 | ||
PAK4-IN-1 is a selective, potent, orally active PAK4 inhibitor that is stable under both acidic and neutral conditions.PAK4-IN-1 exhibits good anti-tumour effects in vivo. | |||
T61299 | PAK4-IN-2 | ||
PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant pote... | |||
T11826 | LCH-7749944 | GNF-PF-2356 | Apoptosis , PAK |
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w... | |||
T4230 | PF-3758309 hydrochloride | PF-03758309 hydrochloride | Apoptosis , PAK |
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd... | |||
T6626 | PF-3758309 | PF-309,PF-03758309,PF 3758309 | Apoptosis , PAK |
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition. | |||
T16429 | GNE 2861 | PAK | |
GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity. | |||
T6840 | FRAX486 | PAK | |
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. | |||
T6840L | FRAX486 HCL(1232030-35-1 free base) | PAK | |
FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. | |||
T6839 | FRAX1036 | PAK | |
FRAX-1036 is a effective and selective PAK1 inhibitor. | |||
T68823 | SPU-106 | ||
SPU-106 is a novel specific PAK4 inhibitor, effectively inhibiting the invasion of SGC7901 cells without cytotoxicity, regulating the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. | |||
T71196 | KY-04045 | ||
KY-04045 is a PAK4 inhibitor. | |||
T27115 | CZh226 | CZh-226,CZh 226 | |
CZh226 is a potent and selective PAK4 inhibitor (PAK4 Ki = 9 nM; PAK1 Ki = 3112 nM). CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways i... | |||
T63984 | PF-3758309 dihydrochloride | ||
PF-3758309 dihydrochloride is a potent, reversible, orally active, ATP-competitive PAK4 inhibitor with a Kd value of 2.7 nM and a Ki value of 18.7 nM. PF-3758309 dihydrochloride exhibits the expected cellular functions o... |