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Catalog No. T6839   CAS 1432908-05-8

FRAX-1036 is a effective and selective PAK1 inhibitor.

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FRAX1036, CAS 1432908-05-8
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FRAX-1036 is a effective and selective PAK1 inhibitor.
Targets&IC50 PAK1:23.3 nM(Ki), PAK2:72.4 nM(Ki), PAK4:2.4 μM(Ki)
In vitro MDA-MB-175 cells,which are PAK1-amplified (MEK1-S298 and CRAF-S338) ,was observed Potent cellular inhibition at 2.5 to 5 μM concentrations of FRAX1036. PAK1-amplified breast cancer cells are treated with FRAX1036 leading to apoptosis. OVCAR-3 cells are treated with FRAX-1036 resulting in upregulation of p53 and p21, while down-regulating cyclin B1.
In vivo KT21 are treated with Frax1036 showing slower tumor growth, while Frax1036 is unlikely to have significant blood-brain barrier permeability in mice.
Cell Research MDA-MB175 cells are treated with increasing concentrations (0, 0.5, 1, 2.5, 5 μM) of FRAX1036 for 24 hours.
Animal Research Pak2-deficient mice were treated by oral gavage of 30 mg/kg Frax1036.
Molecular Weight 518.06
Formula C28H32ClN7O
CAS No. 1432908-05-8


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ong CC, et al. Breast Cancer Res. 2015, 17:59. 2. Kosoff RE, et al. Blood. 2015, 125(19):21995-32005. 3. Alexander B. Koval, et al. Tetrahedron Letters. 2016, 57(3):449-451. 4. Chow HY, et al. Oncotarget. 2015, 6(4): 1981-1994.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Inhibitor Library Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Fingolimod FRAX486 PF-3758309 IPA-3 ZINC194100678 PF-3758309 hydrochloride AZ13705339 GNE 2861

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FRAX1036 1432908-05-8 细胞骨架 PAK FRAX 1036 Inhibitor p21 activated kinases inhibit FRAX-1036 inhibitor