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FRAX1036

FRAX1036
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Purity:99.95%
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FRAX1036

Catalog No. T6839Cas No. 1432908-05-8
FRAX-1036 is a effective and selective PAK1 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$47In Stock
2 mg$63In Stock
5 mg$89In Stock
10 mg$122In Stock
25 mg$222In Stock
50 mg$372In Stock
100 mg$538In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Product Introduction

Bioactivity
Description
FRAX-1036 is a effective and selective PAK1 inhibitor.
In vitro
MDA-MB-175 cells,which are PAK1-amplified (MEK1-S298 and CRAF-S338) ,was observed Potent cellular inhibition at 2.5 to 5 μM concentrations of FRAX1036. PAK1-amplified breast cancer cells are treated with FRAX1036 leading to apoptosis. OVCAR-3 cells are treated with FRAX-1036 resulting in upregulation of p53 and p21, while down-regulating cyclin B1.
In vivo
KT21 are treated with Frax1036 showing slower tumor growth, while Frax1036 is unlikely to have significant blood-brain barrier permeability in mice.
Cell Research
MDA-MB175 cells are treated with increasing concentrations (0, 0.5, 1, 2.5, 5 μM) of FRAX1036 for 24 hours.
Animal Research
Pak2-deficient mice were treated by oral gavage of 30 mg/kg Frax1036.
Chemical Properties
Molecular Weight518.05
FormulaC28H32ClN7O
Cas No.1432908-05-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: insoluble

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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