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Search Results for " p2x2/3 "

15

Compounds

Cat No. Product Name Synonyms Targets
TQ0002 A-317491 ABT 202 P2X Receptor
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T75162 P2X2/3 modulator-1
P2X2/3 Modulator-1 (Compound 46) serves as a modulator of P2X2/3 receptors and has applications in researching pain, central nervous system disorders, and inflammation [1].
T40045 Sivopixant S-600918,Sivopixant P2X Receptor
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
T2087 AF-353 Ro-4 P2X Receptor
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T5513 RO-3 P2X Receptor
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T8436 Minodronic acid Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529 Apoptosis , P2X Receptor
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the ...
T23245 Ro-51 Ro 51 Others
dual P2X3 and P2X2/3 antagonist
T67885 Camlipixant BLU-5937 P2X Receptor
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment o...
T23442 TC-P 262 Others
P2X3 and P2X2/3 receptor antagonist
T5099 Gefapixant RO 4926219,AF219,MK-7264 P2X Receptor
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
TQ0002L A-317491 sodium A-317491,A 317491,A317491
A-317491 is an effective selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which reverses inflammatory mechanical hyperalgesia and relieves chronic inflammation and neuropathic pain in rats by acting on p...
T10560 P2X3 antagonist 34 BLU-5937
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It s...
T10204 A-317491 sodium salt hydrate A-317491 sodium salt hydrate (475205-49-3 free base) Others
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
T83802 TNP-ATP sodium
TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to...
T83820 TNP-GTP sodium TNP-Guanosine 5'-triphosphate
TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i...
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