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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0002 | A-317491 | ABT 202 | P2X Receptor |
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. | |||
T75162 | P2X2/3 modulator-1 | ||
P2X2/3 Modulator-1 (Compound 46) serves as a modulator of P2X2/3 receptors and has applications in researching pain, central nervous system disorders, and inflammation [1]. | |||
T40045 | Sivopixant | S-600918,Sivopixant | P2X Receptor |
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . | |||
T2087 | AF-353 | Ro-4 | P2X Receptor |
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0). | |||
T5513 | RO-3 | P2X Receptor | |
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor | |||
T8436 | Minodronic acid | Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529 | Apoptosis , P2X Receptor |
Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the ... | |||
T23245 | Ro-51 | Ro 51 | Others |
dual P2X3 and P2X2/3 antagonist | |||
T67885 | Camlipixant | BLU-5937 | P2X Receptor |
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment o... | |||
T23442 | TC-P 262 | Others | |
P2X3 and P2X2/3 receptor antagonist | |||
T5099 | Gefapixant | RO 4926219,AF219,MK-7264 | P2X Receptor |
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. | |||
TQ0002L | A-317491 sodium | A-317491,A 317491,A317491 | |
A-317491 is an effective selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which reverses inflammatory mechanical hyperalgesia and relieves chronic inflammation and neuropathic pain in rats by acting on p... | |||
T10560 | P2X3 antagonist 34 | BLU-5937 | |
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It s... | |||
T10204 | A-317491 sodium salt hydrate | A-317491 sodium salt hydrate (475205-49-3 free base) | Others |
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. | |||
T83802 | TNP-ATP sodium | ||
TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to... | |||
T83820 | TNP-GTP sodium | TNP-Guanosine 5'-triphosphate | |
TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i... |