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A-317491 sodium

Catalog No. TQ0002L CAS TQ0002L

Synonyms: A-317491, A 317491, A317491

A-317491 is an effective selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which reverses inflammatory mechanical hyperalgesia and relieves chronic inflammation and neuropathic pain in rats by acting on peripheral receptors.

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A-317491 sodium, CAS TQ0002L

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	A-317491, A 317491, A317491
Molecular Weight	631.12
Formula	C33H24NNa3O8
CAS No.	TQ0002L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang WS, Tu WZ, Cheng RD, He R, Ruan LH, Zhang L, Gong YS, Fan XF, Hu J, Cheng B, Lai YP, Zou EM, Jiang SH. Electroacupuncture and A-317491 depress the transmission of pain on primary afferent mediated by the P2X3 receptor in rats with chronic neuropathic pain states. J Neurosci Res. 2014 Dec;92(12):1703-13. doi: 10.1002/jnr.23451. Epub 2014 Jul 17. PubMed PMID: 25041872. 2. Hansen RR, Nasser A, Falk S, Baldvinsson SB, Ohlsson PH, Bahl JM, Jarvis MF, Ding M, Heegaard AM. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):27-34. doi: 10.1016/j.ejphar.2012.05.008. Epub 2012 May 22. PubMed PMID: 22634164. 3. Ito K, Iwami A, Katsura H, Ikeda M. Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):483-90. Epub 2007 Oct 5. PubMed PMID: 17917716. 4. Wu G, Whiteside GT, Lee G, Nolan S, Niosi M, Pearson MS, Ilyin VI. A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53. PubMed PMID: 15507220.

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Keywords

A-317491 sodium TQ0002L A 317491 sodium A317491 sodium A-317491 A 317491 A317491 inhibitor inhibit

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