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Search Result

Search Results for " ox2 "

Targets

OX Receptor

35

Compounds

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T4965 TCS-OX2-29 OX Receptor
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
T4965L TCS-OX2-29 HCl TCSOX 229,TCS-OX229,TCS OX229,TCS OX2 29,TCSOX-229,TCSOX229
TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation.
T1823 IOX2 IOX 2,JICL38 HIF/HIF Prolyl-Hydroxylase
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
T62855 OX2R-IN-1
OX2R-IN-1 is an OX2R antagonist (a potential OX2R binding agent) that exhibits low cytotoxicity (IC50: 484 μM). oX2R-IN-1 has blood-brain barrier permeability and a short drug half-life.
T82630 CysOx2
CysOx2 is a fluorogenic probe designed for the detection of sulfenic acid, exhibiting an excitation/emission profile of 394/535 nm. It is specifically utilized for monitoring protein cysteine oxidation within living cell...
T81648 NOX2-IN-1
NOX2-IN-1 (compound 10) serves as an inhibitor of the enzyme nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). It specifically disrupts the p47phox-p22phox protein-protein interaction, exhibiting high...
T81647 NOX2-IN-2
NOX2-IN-2 (compound 33) is a potent inhibitor of NOX2, disrupting the p47phox-p22phox protein-protein interaction with a dissociation constant (K i) of 0.24 μM. It effectively suppresses reactive oxygen species (ROS) pro...
T2613 Almorexant ACT 078573 OX Receptor
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T2710 TCS 1102 OX Receptor
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T5503 IPSU OX Receptor
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
TP1045L Orexin B, rat, mouse Acetate Rat orexin B,Orexin B (mouse) Acetate,Orexin B, rat, mouse Acetate(202801-92-1 free base) OX Receptor
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
TP1973L OXA (17-33) acetate OX Receptor
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
T5498 SB-649868 GSK649868 OX Receptor
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
T11186 EMPA OX Receptor
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively)
T6658 SB-408124 OX Receptor
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
T1913 MK-3697 OX Receptor
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
TP1975L [Ala11,D-Leu15]-Orexin B acetate [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) OX Receptor
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).
T16854 SB-674042 SB674042 OX Receptor
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively.SB-674042 can be used for the treatment of depression.
T16096 Filorexant MK-6096 OX Receptor
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
T6140 SB-334867 free base SB334867A free base,SB-334867,SB 334867,SB334867 OX Receptor
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
T39229 YNT-185 OX Receptor
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of ...
T12877L Seltorexant JNJ-42847922 OX Receptor
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a...
T6155 Almorexant hydrochloride ACT-078573 hydrochloride,Almorexant HCl OX Receptor
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T37112 YNT-185 dihydrochloride
Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depo...
TP1975 [Ala11,D-Leu15]-Orexin B(human) [Ala11,D-Leu15]-Orexin B
Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
T22880 JNJ-10397049 JNJ 10397049 Others
OX2 receptor antagonist
T75921 [Ala11,D-Leu15]-Orexin B(human) TFA
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent, selective agonist for the orexin-2 receptor (OX2), demonstrating 400-fold higher selectivity for OX2 (EC 50 =0.13 nM) compared to the orexin-1 receptor (OX1) with an EC 50...
T75920 Orexin B, human TFA
Orexin B, human (TFA), functions as a native agonist for the Orexin receptor, exhibiting dissociation constants (Kis) of 420 nM for OX1 and 36 nM for OX2, respectively.
TP1045 Orexin B, rat, mouse Orexin B (mouse),Rat orexin B
Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
T75922 OXA(17-33) TFA
OXA(17-33) TFA is a potent, selective agonist for the orexin-1 receptor (OX1), demonstrating about 23-fold higher affinity for OX1 (EC50 = 8.29 nM) compared to the orexin-2 receptor (OX2) (187 nM) [1].
TP1973 OXA(17-33) OXA (17-33)
Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.
TP1139 Orexin B, human Human orexin B
Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. Orexin B is a hypothalamatic neuropeptide stimulating food intake in rats.
TP1138 Orexin B, human TFA (205640-91-1 free base) Orexin B, human TFA,Human orexin B TFA
Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2.
T75925 Orexin B, rat, mouse TFA
Orexin B, rat, mouse (Rat orexin B) TFA, an endogenous agonist for orexin receptors, binds to and activates the closely related orphan G protein-coupled receptors OX1-R and OX2-R. This compound is instrumental in stimula...
TP1550 Orexin A (human, rat, mouse) (TFA)
Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and o...

Compounds

TCS-OX2-29
T4965
Synonym:
Target: OX Receptor
TCS-OX2-29 HCl
T4965L
Synonym: TCSOX 229,TCS-OX229,TCS OX229,TCS OX2 29,TCSOX-229,TCSOX229
Target:
IOX2
T1823
Synonym: IOX 2,JICL38
Target: HIF/HIF Prolyl-Hydroxylase
OX2R-IN-1
T62855
Synonym:
Target:
CysOx2
T82630
Synonym:
Target:
NOX2-IN-1
T81648
Synonym:
Target:
NOX2-IN-2
T81647
Synonym:
Target:
Almorexant
T2613
Synonym: ACT 078573
Target: OX Receptor
TCS 1102
T2710
Synonym:
Target: OX Receptor
IPSU
T5503
Synonym:
Target: OX Receptor
Orexin B, rat, mouse Acetate
TP1045L
Synonym: Rat orexin B,Orexin B (mouse) Acetate,Orexin B, rat, mouse Acetate(202801-92-1 free base)
Target: OX Receptor
OXA (17-33) acetate
TP1973L
Synonym:
Target: OX Receptor
SB-649868
T5498
Synonym: GSK649868
Target: OX Receptor
EMPA
T11186
Synonym:
Target: OX Receptor
SB-408124
T6658
Synonym:
Target: OX Receptor
MK-3697
T1913
Synonym:
Target: OX Receptor
[Ala11,D-Leu15]-Orexin B acetate
TP1975L
Synonym: [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base)
Target: OX Receptor
SB-674042
T16854
Synonym: SB674042
Target: OX Receptor
Filorexant
T16096
Synonym: MK-6096
Target: OX Receptor
SB-334867 free base
T6140
Synonym: SB334867A free base,SB-334867,SB 334867,SB334867
Target: OX Receptor
YNT-185
T39229
Synonym:
Target: OX Receptor
Seltorexant
T12877L
Synonym: JNJ-42847922
Target: OX Receptor
Almorexant hydrochloride
T6155
Synonym: ACT-078573 hydrochloride,Almorexant HCl
Target: OX Receptor
YNT-185 dihydrochloride
T37112
Synonym:
Target:
[Ala11,D-Leu15]-Orexin B(human)
TP1975
Synonym: [Ala11,D-Leu15]-Orexin B
Target:
JNJ-10397049
T22880
Synonym: JNJ 10397049
Target: Others
[Ala11,D-Leu15]-Orexin B(human) TFA
T75921
Synonym:
Target:
Orexin B, human TFA
T75920
Synonym:
Target:
Orexin B, rat, mouse
TP1045
Synonym: Orexin B (mouse),Rat orexin B
Target:
OXA(17-33) TFA
T75922
Synonym:
Target:
OXA(17-33)
TP1973
Synonym: OXA (17-33)
Target:
Orexin B, human
TP1139
Synonym: Human orexin B
Target:
Orexin B, human TFA (205640-91-1 free base)
TP1138
Synonym: Orexin B, human TFA,Human orexin B TFA
Target:
Orexin B, rat, mouse TFA
T75925
Synonym:
Target:
Orexin A (human, rat, mouse) (TFA)
TP1550
Synonym:
Target:

Recombinant Proteins

Species：
Human (7)
Mouse (2)
Cynomolgus (1)
Expression System：
HEK293 Cells (8)
E. coli (2)
Tag：
C-His (3)
C-6xHis (1)
C-hFc (1)
His (1)
His, Avi (1)
N-10xHis, C-Myc (1)
Tag Free (1)
hFc, Avi (1)
Cat No. Product Name Species Expression System
TMPY-05446 CD200 Protein, Human, Recombinant (hFc) Human HEK293 Cells
CD200 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.2 kDa and the accession number is A0A2R9ADU6.
TMPY-01160 CD200 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
CD200 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is O54901.1.
TMPY-05638 CD200 Protein, Human, Recombinant (hFc & Avi) Human HEK293 Cells
CD200 Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 51 kDa and the accession number is P41217-2.
TMPK-00733 CD200 Protein, Mouse, Recombinant (aa 31-232, His) Mouse HEK293 Cells
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 rece...
TMPY-01071 CD200 Protein, Human, Recombinant (His) Human HEK293 Cells
CD200 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P41217-2.
TMPY-06791 CD200 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
CD200 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.71 kDa and the accession number is NP_005935.4.
TMPK-00476 CD200 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 rece...
TMPJ-00233 CD200R1/CRTR2 Protein, Human, Recombinant (His) Human HEK293 Cells
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...
TMPH-01277 ENOX2 Protein, Human, Recombinant Human E. coli
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a ...
TMPH-01278 ENOX2 Protein, Human, Recombinant (His & Myc) Human E. coli
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a ...
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