nae — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8816	NAE-IN-M22	NEDD8 inhibitor M22	Apoptosis , E1/E2/E3 Enzyme
	NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i...		Apoptosis , E1/E2/E3 Enzyme
T6332	Pevonedistat	MLN4924	E1/E2/E3 Enzyme , NEDD8
	Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.		E1/E2/E3 Enzyme , NEDD8
T13090	TAS4464 hydrochloride		E1/E2/E3 Enzyme , NEDD8
	TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).		E1/E2/E3 Enzyme , NEDD8
T5374	NAcM-OPT		E1/E2/E3 Enzyme , NEDD8
	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).		E1/E2/E3 Enzyme , NEDD8
T16335	Nonaethylene glycol monododecyl ether	Nonaoxyethylene monododecyl ether,Polidocanol	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) is a nonionic surfactant and polyethylene glycol (PEG) detergent. It can be used to form initial coalesced O/W emulsion droplets and for protein separation and purifica...		Others
T76249	RNAENFDRF
	RNAENFDRF (βIIPKC624-632) conjugated to TAT47-57, a cell-permeable peptide, forms SAMβA, a rationally designed peptide that selectively antagonizes Mfn1-βIIPKC association. SAMβA acts as a selective inhibitor of mitofusi...
T16337	Nonaethylene glycol		Others
	Nonaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome syst...		Others
T16336	Nonaethylene glycol monomethyl ether		Others
	Nonaethylene glycol monomethyl ether, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].		Others
T25847	NAEPA
	NAEPA, an LPA mimetic, is a selective agonist of the lysophosphatidic acid-1 (LPA1) receptor.
T76249L	RNAENFDRF TFA
	RNAENFDRF (βIIPKC624-632) TFA is conjugated to the cell permeable peptide TAT47-57, which can be used to form an inhibitory peptide SAMβA. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAM...
T33578	Naepaine hydrochloride
	Naepaine hydrochloride is a biochemical.
T124493	Senaetnine
	Senaetnine is a useful organic compound for research related to life sciences and the catalog number is T124493.
T126132	Tabernaecorymbosine A
	Tabernaecorymbosine A is a useful organic compound for research related to life sciences and the catalog number is T126132.
T13412	ZM223	ZM-223	E1/E2/E3 Enzyme
	ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).		E1/E2/E3 Enzyme
T16102	ML-792		E1/E2/E3 Enzyme
	ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...		E1/E2/E3 Enzyme
T63800	ZM223 hydrochloride
	ZM223 hydrochloride is a potent, non-covalent, orally active inhibitor of NEDD8 activase (NAE).
T68059	Ebalzotan
	NAE-086 is a high-affinity and selective 5-HT(1A) receptor ligand with a K(i) value of 4.5 nM in membranes from rat hippocampus.
T69577	LEI-301
	LEI-301 is a novel potent inhibitor for the PLAAT family members, reducing the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5.
T28007	MDPD
	MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabid...
T13412L	ZM223 hydrochloride (2031177-48-5 free base)	ZM223 hydrochloride	Serine Protease
	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.		Serine Protease