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ZM223 hydrochloride (2031177-48-5 free base)

Catalog No. T13412L CAS T13412L

Synonyms: ZM223 hydrochloride

ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.

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ZM223 hydrochloride (2031177-48-5 free base) Chemical Structure

ZM223 hydrochloride (2031177-48-5 free base), CAS T13412L

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 398.00
10 mg	Inquiry	$ 663.00
50 mg	Inquiry	$ 1,981.00
100 mg	Inquiry	$ 2,949.00
200 mg	Inquiry	Inquiry
500 mg	Inquiry	Inquiry
1 mL * 10 mM (in DMSO)	Inquiry	$ 472.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
In vitro	ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells(IC50s of 100 and 122 nM, respectively).

Synonyms	ZM223 hydrochloride
Molecular Weight	538.99
Formula	C23H18ClF3N4O2S2
CAS No.	T13412L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (278.30 mM), Sonification is recommended.

References and Literature

1. Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ZM223 hydrochloride (2031177-48-5 free base) T13412L Proteases/Proteasome Serine Protease 2031177-48-5 ZM223 Hydrochloride ZM-223 hydrochloride (2031177-48-5 free base) ZM 223 Hydrochloride ZM-223 Hydrochloride ZM223 hydrochloride (2031177485 free base) ZM223 hydrochloride (2031177 48 5 free base) 2031177-48-5 free base ZM223 hydrochloride inhibitor inhibit

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