19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16163 | MV1 | Apoptosis | |
MV1 is an antagonist of IAP. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins. | |||
T18613 | MV-1-NH-Me | PROTAC IAP binding moiety 2 | Others |
MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1]. | |||
T18685 | SNIPER(ABL)-015 | Others | |
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5 μM [1]. | |||
T18686 | SNIPER(ABL)-019 | Others | |
SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1]. | |||
T18694 | SNIPER(ABL)-050 | Others | |
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1]. | |||
T18692 | SNIPER(ABL)-047 | Others | |
SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 μM[1]. | |||
T15399 | GNE-207 | Epigenetic Reader Domain | |
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expres... | |||
T79391 | FLT3-IN-21 | ||
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-... | |||
T75333 | Quinine hemisulfate hydrate | ||
Quinine hemisulfate hydrate, an alkaloid extracted from the cinchona tree bark, serves as an anti-malarial agent and potassium channel inhibitor. It specifically targets and inhibits WT mouse Slo3 (K Ca 5.1) channel curr... | |||
T78647 | PROTAC BRD4 Degrader-16 | PROTACs | |
PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression,... | |||
T74270 | PROTAC BRD4 Degrader-17 | ||
PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and signifi... | |||
T82393 | FLT3/CHK1-IN-1 | ||
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr... | |||
T82567 | Di-4-ANEPPS | ||
Di-4-ANEPPS, a voltage-sensitive dye, is utilized for detecting membrane potential changes, offering a time resolution under 1 ms and fluorescence variations up to 10% per 100 mV. Widely used for cardiac electrical activ... | |||
T79456 | FD1024 | Pim | |
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demonstrates significant antiproliferative effects on several AML... | |||
T61005 | K783-0308 | ||
K783-0308 is a potent and selective MNK2 and FLT3 dual inhibitor with IC 50 values of 406 and 680 nM, respectively. K783-0308 promotes the apoptosis and cell cycle arrests in the G0/G1 phase of acute myeloid leukemia (AM... | |||
T79322 | Antiproliferative agent-30 | ||
Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It... | |||
T28269 | ORY-1001 free base | RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016 | |
ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/do... | |||
T36215 | 17R(18S)-EpETE | ||
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren... | |||
T39937 | M-808 | ||
M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM. |