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Search Results for " mmaf "

20

Compounds

Cat No. Product Name Synonyms Targets
T3256 MMAF MonoMethyl auristatin F Others , Microtubule Associated
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T12081 MMAF-OMe Monomethyl auristatin F methyl ester
MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji ...
T39897 DBCO-PEG4-MMAF DBCO-PEG4-MMAF
DBCO-PEG4-MMAF is an antibody-drug conjugate (ADC) component that exhibits potent antitumor activity. It combines the tubulin polymerization inhibitor MMAF with a cleavable linker, DBCO-PEG4, to target cancer cells effec...
T38830 Modified MMAF-C5-COOH Modified MMAF-C5-COOH
Modified MMAF-C5-COOH is a drug-linker conjugate for ADC.
T39238 DBM-MMAF
DBM-MMAF is a drug-linker conjugate composed of a potent antitubulin agent MMAF and a linker DBM to make antibody drug conjugate (ADC).
T39748 DBCO-PEG4-Val-Cit-PAB-MMAF DBCO-PEG4-Val-Cit-PAB-MMAF
DBCO-PEG4-Val-Cit-PAB-MMAF is a chemical compound that comprises a cleavable 4 unit polyethylene glycol antibody-drug conjugate (ADC) linker known as DBCO-PEG4-Val-Cit-PAB, and a highly effective inhibitor of tubulin pol...
T16121 MMAF Hydrochloride Monomethylauristatin F Hydrochloride Others
MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used ...
T10949 D8-MMAF Monomethylauristatin F D8 Others
D8-MMAF is a microtubule destroyer, deuterated form of MMAF.
T19269 D8-MMAF hydrochloride Others
D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.
T16122 MMAF sodium Monomethylauristatin F sodium ABC
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumo...
T27975 MAL-PEG4-MMAF
MAL-PEG4-MMAF is a maleimido functionalized derivative of MMAF (Monomethyl auristatin F) with PEG4 linker. The maleimido functional group can be easily conjugated to protein carriers (such as antibody or enzyme). MAL-PEG...
T18534 PEG4-aminooxy-MMAF Others
PEG4-aminooxy-MMAF is a drug-linker conjugate designed for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. It incorporates MMAF, a powerful antitubulin agent, connected through a non-cleavable PEG...
T18306 MC-Alkyl-Hydrazine Modified MMAF Others
MC-Alkyl-Hydrazine Modified MMAF is a potent antitumor drug-linker conjugate for ADC, incorporating Modified MMAF, a tubulin inhibitor, through a noncleavable MC-Alkyl-Hydrazine linkage[1].
T18326 MC-Val-Cit-PAB-MMAF Others
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavabl...
T18251 MAL-di-EG-Val-Cit-PAB-MMAF Others
MAL-di-EG-Val-Cit-PAB-MMAF refers to a chemical compound that comprises the linker (MAL-di-EG-Val-Cit-PAB) and the potent blocker of tubulin polymerization (MMAF, Monomethyl auristatin F)[1].
T74177 Modified MMAF
Modified MMAF, a cytotoxin for antibody-drug conjugates (ADC), facilitates the synthesis of ADCs tailored for targeted cancer research [1].
T83129 Amidate-VC-PAB-MMAF
Amidate-VC-PAB-MMAF, a cleavable ADC linker (Amidate-VC-PAB) combined with a potent tubulin polymerization inhibitor (MMAF), is utilized in the synthesis of antibody-drug conjugates (ADCs) to decrease off-target cytotoxi...
T82382 Fmoc-MMAF-OMe
Fmoc-MMAF-OMe is a tubulin polymerization inhibitor and anticancer agent featuring an Fmoc protecting group. Its active component, MMAF, serves as the cytotoxic (ADC Cytotoxin) element in conventional antibody-drug conju...
T80883 Val-Cit-PAB-MMAF
Val-Cit-PAB-MMAF is an agent-linker conjugate utilized for antibody-drug conjugates (ADCs), consisting of the peptide linker Val-Cit-PAB and the potent tubulin polymerization inhibitor known as MMAF [1].
T77894 Val-Cit-PAB-MMAF sodium
Val-Cit-PAB-MMAF sodium is an agent-linker conjugate used in antibody-drug conjugates (ADCs), consisting of the peptide linker Val-Cit-PAB and the cytotoxic agent monomethyl auristatin F (MMAF), which inhibits tubulin po...
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