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D8-MMAF hydrochloride

Catalog No. T19269 CAS T19269

D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.

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D8-MMAF hydrochloride Chemical Structure

D8-MMAF hydrochloride, CAS T19269

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.
In vitro	MMAF showed cytotoxicity in vitro against a group of cell lines. Karpas 299, H3396, 786-O and Caki-1 have IC50 values of 119, 105, 257 and 200 nM, respectively. Targeted MMAF is more effective than free drug, and the cAC10 conjugate of MMAF shows significant activity. On a molar basis, cAC10-L1-MMAF4 is on average more than 2200 times more potent than free MMAF and is active in all CD30-positive cell lines tested.
In vivo	The maximum tolerated dose of MMAF (> 16 mg / kg) mice is much higher than that of MMAE (1 mg / kg). The MTD of cAC10-L1-MMAF4 is 50 mg / kg in mice and 15 mg / kg in rats. The corresponding cAC10-L4-MMAF4 ADC is much less toxic, with MTDs greater than 150 mg / kg and 90 mg / kg in mice and rats, respectively.

Molecular Weight	776.47
Formula	C39H58D8ClN5O8
CAS No.	T19269

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D8-MMAF hydrochloride T19269 Others D-8-MMAF hydrochloride D8 MMAF hydrochloride D8MMAF hydrochloride D8-MMAF Hydrochloride inhibitor inhibit

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