Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | Inquiry | |
50 mg | 10-14 weeks | Inquiry | |
100 mg | 10-14 weeks | Inquiry |
Description | MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound. |
In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
In vivo | cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively. The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg) [4]. |
Synonyms | Monomethylauristatin F Hydrochloride |
Molecular Weight | 768.42 |
Formula | C39H66ClN5O8 |
CAS No. | 1415246-68-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27 mg/mL (35.14 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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MMAF Hydrochloride 1415246-68-2 Others Monomethylauristatin F Hydrochloride inhibitor inhibit