Powder: -20°C for 3 years
In solvent: -80°C for 2 years
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
Description | MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent. |
In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
Synonyms | Monomethylauristatin F sodium |
Molecular Weight | 754.966 |
Formula | C39H65N5NaO8 |
CAS No. | 1799706-65-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 200 mg/mL (265.27 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MMAF sodium 1799706-65-2 离子通道 ABC Monomethylauristatin F sodium Inhibitor inhibitor inhibit