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MMAF sodium

Catalog No. T16122 CAS 1799706-65-2

Synonyms: Monomethylauristatin F sodium

MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.

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MMAF sodium, CAS 1799706-65-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
In vitro	MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].

Synonyms	Monomethylauristatin F sodium
Molecular Weight	754.966
Formula	C39H65N5NaO8
CAS No.	1799706-65-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 200 mg/mL (265.27 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70. 2. Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4. 3. Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics. 4. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

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Keywords

MMAF sodium 1799706-65-2 离子通道 ABC Monomethylauristatin F sodium Inhibitor inhibitor inhibit

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