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MMAF sodium

MMAF sodium
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MMAF sodium

Catalog No. T16122Cas No. 1799706-65-2
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
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Pack SizePriceAvailabilityQuantity
25 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
100 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
In vitro
MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].
AliasMonomethylauristatin F sodium
Chemical Properties
Molecular Weight754.966
FormulaC39H65N5NaO8
Cas No.1799706-65-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 200 mg/mL (265.27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3246 mL6.6228 mL13.2456 mL66.2281 mL
5 mM0.2649 mL1.3246 mL2.6491 mL13.2456 mL
10 mM0.1325 mL0.6623 mL1.3246 mL6.6228 mL
20 mM0.0662 mL0.3311 mL0.6623 mL3.3114 mL
50 mM0.0265 mL0.1325 mL0.2649 mL1.3246 mL
100 mM0.0132 mL0.0662 mL0.1325 mL0.6623 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg, each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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2 Enter the in vivo formulation:
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