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Search Results for " mgmt "

7

Compounds

Cat No. Product Name Synonyms Targets
T11419 O6BTG-octylglucoside Glucose-conjugated MGMT inhibitor Others
O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).
T0192 Levetiracetam UCB L059,SIB-S1 DNA Methyltransferase , Others , Calcium Channel
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...
T2495 Lomeguatrib PaTrin-2 DNA Methyltransferase , DNA Alkylation
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T7539 O6-Benzylguanine Apoptosis , DNA Alkylation , DNA/RNA Synthesis
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T26496 AA-CW236 AA-CW 236,AACW-236,AACW236,AACW 236,AA-CW-236
AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).
T36100 K-TMZ
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lin...
T60281 MPO-IN-4
MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC 50 of 25 nM. MPO-IN-4 also demonstrates inhibition of thyroid peroxidase (TPO) with IC50 of 2.2 μM. MPO-IN-4 has no effect on me...
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