Search Result

Search Results for " mgl "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3595	Resmetirom	VIA-3196,MGL3196	Thyroid hormone receptor(THR)
	Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.		Thyroid hormone receptor(THR)
T7688	4-Nonylphenylboronic acid		FAAH
	4-Nonylphenylboronic acid is a inhibitor of FAAH.		FAAH
T12717	Basimglurant	CTEP Derivative,RG7090	GluR
	Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).		GluR
T9970	mGluR3 modulator-1	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile	GluR
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.		GluR
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) can be used in antipsychotic research. mGluR2 modulator 2 is a potent, selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC 50 value of 0.13 μM [1].
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ...
T81801	mGluR5 antagonist-1
	mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p...
T38659	mGluR5 modulator 1
	mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment...
T74287	MGlc-DAG
	MGlc-DAG, a glycoglycerolipid, serves as a precursor in the synthesis of drug delivery compounds [1].
T61775	mGlu4 receptor agonist 1
	mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [...
T3591	URB602		Lipase , Antibacterial
	URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.		Lipase , Antibacterial
T28165	NF-1819	NF 1819,NF1819	Lipase
	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model ...		Lipase
T71493	AM6580
	AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
T34521	SAR629	SAR 629,SAR-629
	SAR-629 is an MGL inhibitor or 2-AG degradation inhibitor.
T61294	Monoacylglycerol lipase inhibitor 1
	Monoacylglycerol lipase inhibitor 1, also known as compound 13 [1], is a potent inhibitor of monoacylglycerol lipase.

Compounds

Resmetirom

T3595

Synonym: VIA-3196,MGL3196

Target: Thyroid hormone receptor(THR)

4-Nonylphenylboronic acid

Synonym: CTEP Derivative,RG7090

Target: GluR

mGluR3 modulator-1

T9970

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

mGluR2 antagonist 1

T38910

Synonym:

Target:

mGluR5 antagonist-1

mGlu4 receptor agonist 1

Target: Lipase, Antibacterial

NF-1819

T28165

Synonym: NF 1819,NF1819

Synonym: SAR 629,SAR-629

Target:

Monoacylglycerol lipase inhibitor 1

T61294

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T5737	Euphol		Others , Lipase , Endogenous Metabolite
	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.		Others , Lipase , Endogenous Metabolite
T4S1050	Pristimerin	Celastrol methyl ester	NF-κB , Antibacterial
	1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...		NF-κB , Antibacterial

Natural Products

euphol

T5737

Synonym:

Target: Others, Lipase, Endogenous Metabolite

Pristimerin

T4S1050

Synonym: Celastrol methyl ester

Target: NF-κB, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.
TMPY-02405	CLEC10A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CLEC10A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.7 kDa and the accession number is F8WHB7.
TMPY-02459	CLEC10A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CLEC10A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.7 kDa and the accession number is F8WHB7.
TMPJ-01217	Mgl2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Macrophage galactose N-acetyl-galactosamine-specific lectin 2(Mgl2), also known as CD301b, is a 38 kDa member that belongs to the C-type lectin family. Two MGL proteins are encoded by separate genes in the mouse, but sha...
TMPH-03475	MglB Protein, Salmonella typhimurium, Recombinant (His)	Salmonella typhimurium	P. pastoris (Yeast)
	This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. MglB Protein, Salmonella typhimurium, Recombi...
TMPH-03337	MGLL Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception o...
TMPJ-00201	CLEC10A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds a...