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Search Results for " mertk "

Targets

12

Compounds

14

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7007 UNC2025 mrx-6313,UNC-2025,UNC 2025 FLT , TAM Receptor
UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.
T17205 UNC2541 Others , FLT , TAM Receptor
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
T16144 MRX-2843 UNC2371 Others , FLT
MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).
T60197 UNC 1025 Others
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format...
T8327 ONO-7475 Trk receptor , TAM Receptor
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T29062 UNC3133 UNC 3133,UNC-3133
UNC3133 is a potent and selective Mer tyrosine kinase (MerTK) inhibitor with IC50 Mer 3.0 nM; Axl 17nM; Tyro 3.31 nM; FLT3 6.6 nM; PO Cmax = 0.023; IV T1/2 = 1.59 h, %F = 16. Mer tyrosine kinase (MerTK) is aberrantly ele...
T69605 MRX-2843 trihydrochloride
MRX-2843 trihydrochloride is a potent and orally active MERTK and FLT3 inhibitor.
T9134 UNC5293
UNC5293 is a potent, orally available and highly MERTK-selective inhibitor with Ki of 190 pM. UNC5293 inhibits MERTK ( IC 50 =0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK pr...
T63444 UNC4203
UNC4203 is a potent, highly selective, orally active MERTK inhibitor that acts on MERTK (IC50: 1.2 nM), AXL (IC50: 140 nM), TYRO3 (IC50: 42 nM) and FLT3 (IC50: 90 nM).
T15808 Merestinib dihydrochloride LY2801653 dihydrochloride ROCK
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK...
T63101 CJ-2360
CJ-2360 is a potent, orally active ALK inhibitor, capable of acting on wild-type ALK (IC50: 2.2 nM) and F1197M (IC50: 4.0 nM), G1269A (IC50: 8.8 nM), L1196M (IC50: 6.3 nM) and S1206Y ALK mutant (IC50: 8.9 nM). CJ-2360 st...
T39474 UNC2025 hydrochloride UNC2025 hydrochloride
UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active Mer/Flt3 inhibitor. It has IC50 values of 0.74 nM and 0.8 nM, respectively, for Mer and Flt3. UNC2025 hydrochloride demonstrates over 45-fold selec...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01143 MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) Human Human Cells
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one...
TMPK-00417 MERTK/Mer Protein, Human, Recombinant (His) Human HEK293
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-01022 MERTK/Mer Protein, Mouse, Recombinant (His) Mouse HEK293
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-00418 MERTK/Mer Protein, Human, Recombinant (mFc) Human HEK293
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPY-00882 Mer Protein, Human, Recombinant (His & hFc) Human HEK293
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04330 Mer Protein, Human, Recombinant Human HEK293
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04830 GAS6 Protein, Mouse, Recombinant (His) Mouse HEK293
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPY-04437 Mer Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-02291 Mer Protein, Mouse, Recombinant (hFc) Mouse HEK293
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04363 Mer Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04747 Mer Protein, Human, Recombinant (aa 578-872) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPK-00901 TYRO3 Protein, Mouse, Recombinant (His) Mouse HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPK-00533 TYRO3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPY-04484 ACK1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell mig...
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