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UNC2025

Catalog No. T7007 CAS 1429881-91-3

Synonyms: mrx-6313, UNC-2025, UNC 2025

UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.

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UNC2025, CAS 1429881-91-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.
Targets&IC50	FLT3:0.8 nM, Mer:0.74 nM
In vitro	In 697 B-ALL cells, UNC-2025 potently inhibits Mer phosphorylation with IC50 of 2.7 nM. In A549 NSCLC and Molm-14 AML cell lines, UNC-2025 causes significant inhibition of colony formation dependent on Mer8 and Flt3. [1] In H2228 and H1299 cell lines, UNC-2025 inhibits MERTK oncogenic signaling downstream, such as basal and stimulated pAKT and pERK1/2. In four NSCLC cell lines, UNC-2025 also induces apoptotic cell death, and decreases colony formation. [2]
In vivo	In mice bearing 697 acute leukemia tumors, UNC-2025 (3 mg/kg, p.o.) shows good solubility and DMPK properties, and results in effective target inhibition. [1] In mice bearing H2228 or A549 tumors, UNC-2025 (50 mg/kg, p.o.) inhibits tumor growth. [2]

Synonyms	mrx-6313, UNC-2025, UNC 2025
Molecular Weight	476.66
Formula	C28H40N6O
CAS No.	1429881-91-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: 8 mg/mL(15.59 mM), Heating is recommended.

DMSO: 25 mg/mL(48.72 mM), Heating is recommended.

References and Literature

1. Zhang W, et al. J Med Chem. 2014, 57(16), 7031-7041. 2. Cummings CT, et al. Mol Cancer Ther. 2015, 14(9), 2014-2022.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Inhibitor Library Angiogenesis related Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

UNC2025 2HCl (1429881-91-3(free base)) AT9283 SGI-1776 Fedratinib CA-4948 R1530 MRX-2843 FLT3-IN-4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC2025 1429881-91-3 Angiogenesis Tyrosine Kinase/Adaptors FLT TAM Receptor Inhibitor inhibit FLT3 leukemia CD135 Fms like tyrosine kinase 3 acute mrx-6313 Cluster of differentiation antigen 135 cancer MERTK UNC-2025 UNC 2025 inhibitor

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