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Search Results for " loxl2 "

13

Compounds

Cat No. Product Name Synonyms Targets
T39986 LOX-IN-3 dihydrochloride Lipoxygenase
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities.
T7185 (2-Chloropyridin-4-yl)MethanaMine Hydrochloride Monoamine Oxidase
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor(IC50 : 126 nM).
T69913 Lenumlostat PAT-1251,GB2064 Monoamine Oxidase
Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.
T12584 PXS-5120A Others , Monoamine Oxidase
PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.
T12371L PAT-1251 Monoamine Oxidase
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
T60438L PXS-6302 hydrochloride PXS-6302 hydrochloride (2584947-54-4 Free base) Lipoxygenase
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS...
T76700 Simtuzumab GS 6624,AB 0024 Monoamine Oxidase
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...
T4S1383 Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA HIV Protease
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ...
T12585 PXS-5153A Others , Monoamine Oxidase
PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibro...
T12371 PAT-1251 Hydrochloride Others
PAT-1251 Hydrochloride is a potent, selective and oral inhibitor of lysyl oxidase-like 2 (LOXL2)(hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM , respectively),
T12585L PXS-5153A monohydrochloride PXS-5153A monohydrochloride (2125956-82-1 free base) Others
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of <40 nM for LOXL2 across all mammalian species and an IC 50 of 6...
T60438 PXS-6302
PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate...
T60296 PXS-4787
PXS-4787 is a potent and selective inhibitor of lysyl oxidase (LOX) with broad-spectrum activity. It effectively suppresses lysyl oxidase activity by acting on its mechanisms. The compound displays inhibitory effects wit...
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