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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39986 | LOX-IN-3 dihydrochloride | Lipoxygenase | |
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities. | |||
T7185 | (2-Chloropyridin-4-yl)MethanaMine Hydrochloride | Monoamine Oxidase | |
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor(IC50 : 126 nM). | |||
T69913 | Lenumlostat | PAT-1251,GB2064 | Monoamine Oxidase |
Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases. | |||
T12584 | PXS-5120A | Others , Monoamine Oxidase | |
PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity. | |||
T12371L | PAT-1251 | Monoamine Oxidase | |
PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases. | |||
T60438L | PXS-6302 hydrochloride | PXS-6302 hydrochloride (2584947-54-4 Free base) | Lipoxygenase |
PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS... | |||
T76700 | Simtuzumab | GS 6624,AB 0024 | Monoamine Oxidase |
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato... | |||
T4S1383 | Escin IA | Aescin IA,Escin IA;Aescin IA,Escin IA | HIV Protease |
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ... | |||
T12585 | PXS-5153A | Others , Monoamine Oxidase | |
PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibro... | |||
T12371 | PAT-1251 Hydrochloride | Others | |
PAT-1251 Hydrochloride is a potent, selective and oral inhibitor of lysyl oxidase-like 2 (LOXL2)(hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM , respectively), | |||
T12585L | PXS-5153A monohydrochloride | PXS-5153A monohydrochloride (2125956-82-1 free base) | Others |
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of <40 nM for LOXL2 across all mammalian species and an IC 50 of 6... | |||
T60438 | PXS-6302 | ||
PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate... | |||
T60296 | PXS-4787 | ||
PXS-4787 is a potent and selective inhibitor of lysyl oxidase (LOX) with broad-spectrum activity. It effectively suppresses lysyl oxidase activity by acting on its mechanisms. The compound displays inhibitory effects wit... |