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PXS-5153A

Name: PXS-5153A
Brand: TargetMol
SKU: T12585
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12585Cas No. 2125956-82-1

PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

PXS-5153A

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Purity: 99.58%

Catalog No. T12585Cas No. 2125956-82-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$437	In Stock	In Stock
10 mg	$646	In Stock	In Stock
25 mg	$987	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Appearance:Solid

Color:Orange

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.
Targets&IC50	LOXL3:63 nM (human), LOXL2:<40 nM (across all mammalian species)
In vitro	PXS-5153A is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases. PXS-5153A exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested. PXS-5153A also inhibits human LOXL3 with an IC50 value of 63 nM[1].
In vivo	rhLOXL2 dose-dependently induces oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl4 treated animals. Mature crosslink formation is also reduced by PXS-5153A treatment. All groups with therapeutic treatment of PXS-5153A show a significant reduction in DHLNL formation and HYP compared to the CCl4 treated animals[1].

Chemical Properties

Molecular Weight	475.41
Formula	C₂₀H₂₅Cl₂FN₄O₂S
Cas No.	2125956-82-1
Smiles	CC1=C(C2=CC(S(N(C)C)(=O)=O)=CC=C2)C3=NC=CC=C3N1C/C(F)=C/CN.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (42.07 mM), Sonication is recommended.

DMSO: 45 mg/mL (94.66 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1034 mL	10.5172 mL	21.0345 mL	105.1724 mL
5 mM	0.4207 mL	2.1034 mL	4.2069 mL	21.0345 mL
10 mM	0.2103 mL	1.0517 mL	2.1034 mL	10.5172 mL
20 mM	0.1052 mL	0.5259 mL	1.0517 mL	5.2586 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0421 mL	0.2103 mL	0.4207 mL	2.1034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc