jq1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17311	(+)-JQ1 PA		Epigenetic Reader Domain
	(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).		Epigenetic Reader Domain
T10526	β-NF-JQ1		Others
	β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter...		Others
T19618	(R)-(-)-JQ1 Enantiomer		Epigenetic Reader Domain
	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)		Epigenetic Reader Domain
T2110	(+)-JQ-1	JQ1	Epigenetic Reader Domain , Autophagy , Ligands for Target Protein for PROTAC
	(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation.
T18060	KB02-JQ1		Others
	KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modificati...		Others
T70702	JQ1-Acid HCl
	(+)-JQ-1 carboxylic acid is a potent bromodomain and extra terminal domain (BET) inhibitor. (+)-JQ-1 carboxylic has potential to be used as a precursor to synthesize PROTACs and other conjugates.
T74753	JQ1-TCO
	JQ1-TCO (JQ1-trans-cyclooctene), a derivative of the BET inhibitor JQ1, is designed for click chemistry applications, enabling its use as molecular probes both in vitro and in vivo [1] [2].
T62357	ET-JQ1-OH
	ET-JQ1-OH is an allele-specific BET inhibitor.
T74428	Biotinylated-JQ1
	Biotinylated-JQ1 (Biotin-JQ1), a biotinylated derivative of JQ1, selectively binds to the BRD4 bromodomain with high affinity. It effectively inhibits the proliferation of MM1.S multiple myeloma cells, demonstrating an E...
T83929	(+)-JQ1 maleimide
	(+)-JQ1 maleimide, featuring a cysteine-reactive maleimide linked to the BRD4 ligand, JQ1, via a PEG2 linker, serves as a probe suitable for the COFFEE method (COvalent Functionalization Followed by E3 Electroporation). ...
T83931	JQ1-FITC
	JQ1-FITC, a fluorescent BET bromodomain probe, exhibits high affinity binding to BRD4(BD1) and BRD4(BD2), with KD,app values of 6.5 nM and 5.8 nM respectively, as determined using GST-tagged BRD4 proteins in a CoraFluorT...
T81675	NICE-01	AP1867-PEG2-JQ1,AP-PEG2-JQ1
	NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that facilitates the nuclear import of cytosolic cargoes by leveraging the nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for thei...
T5443	JQ-1 (carboxylic acid)	JQ-1 carboxylic acid	Epigenetic Reader Domain
	JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)		Epigenetic Reader Domain
T70700	Calanolide B
	Calanolide B is one of a novel class of HIV-inhibiting coumarins from the tropical rainforest tree, Calophyllum lanigerum.
T12513	PNZ5		Epigenetic Reader Domain
	PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation constant (KD) of 5.43 nM for BRD4(1).		Epigenetic Reader Domain
T4495	DBET1		Epigenetic Reader Domain
	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.		Epigenetic Reader Domain
T4247	I-CBP112 hydrochloride		Epigenetic Reader Domain
	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly re...		Epigenetic Reader Domain
T16312	NH2-PEG3	PROTAC Linker 35	Others
	NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG) linker utilized in the synthesis of PROTAC (β-NF-JQ1)[1].		Others
T13981	β-Naphthoflavone-CH2-Br	β-NF-CH2-Br	Others
	β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.		Others
T75170	BI01826025
	BI01826025 (pArg-JQ1), a PROTAC degrader targeting the bromodomain 1 of BRDT (BRDT BD1), proves useful in exploring the regulatory impact of ClpC2 on the ClpC1P1P2 protease complex [1].