ifnγ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83628	TNF/IFNγ-IN-1		Antioxidant , TNF , COX
	TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.		Antioxidant , TNF , COX
T77433	Feladilimab	GSK3359609	COX , PD-1/PD-L1
	Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist. Feladilimab binds to ICOS-expressing T cells, induces IFNγ, and increases PD-1/L1 expression. Feladilimab has anti-tumor activity and can b...		COX , PD-1/PD-L1
TP2035	FSL-1	FSL 1
	TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.
T80759	XY-52
	XY-52 (Compound 32), an ST2 (Stimulation-2) inhibitor, exhibits IC50 values of 5.68 μM and 4.59 μM in the AlphaLISA and HEK-Blue assays, respectively. It promotes proinflammatory T-cell proliferation and diminishes plasm...
T60921	PF-07038124
	PF-07038124 is an inhibitor of PDE4. The IC50 value of PF-07038124 for PDE4B2 is 0.5 nM. PF-07038124 shows inhibitory activities against IFNγ, IL4, and IL-13 with IC50 values of 1.06, 4.1, and 125 nM, respectively [1].
T62451	TYK2-IN-12
	TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM). TYK2-IN-12 inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respec...
T63026	JAK-IN-19
	JAK-IN-19 is a potent inhibitor of JAK, with pIC50 values of 7.2 and 7.7 for PBMC IFNγ and HLF Eotaxin, respectively. The pIC50 values for VEGFR2 and Aurora B are 7.0 and 5.8 respectively).
T77034	Inbakicept	N-803
	Inbakicept (ALT-803) is an IL-15 superagonist complex, consisting of IL-15 mutant and IL-15Rα-Fc fusion. Inbakicept magnifies anti-CD20 mAb-mediated NK-cell responses and antibody-dependent cellular cytotoxicity (ADCC). ...
T81331	QL-1200186		JAK
	QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following interleukin-12 (IL-12) stimulation and markedly improves skin le...		JAK

Compounds

TNF/IFNγ-IN-1

T83628

Synonym:

Target: Antioxidant, TNF, COX

Feladilimab

T77433

Synonym: GSK3359609

Target: COX, PD-1/PD-L1

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00047	IFN gamma Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experi...
TMPK-00048	IFN gamma Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experi...
TMPK-01385	CRTAM Protein, Canine, Recombinant (His)	Canine	HEK293
	Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of I...
TMPK-00971	CRTAM Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of I...
TMPJ-01422	CRTAM Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
	Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, pe...
TMPJ-00429	CRTAM Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	Human Cells
	Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, pe...
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...