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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1140 | Onjisaponin B | AMPK , mTOR , Autophagy | |
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki... | |||
T8081 | LC3-mHTT-IN-AN1 | Others , Autophagy , ATTECs | |
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner... | |||
T35608 | 16F16 | ||
16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misf... | |||
T39166 | Tominersen | IONIS-HTTRx,RG6042 | |
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen can be used for the research of Hun... | |||
T38146 | Chloroguanabenz (acetate) | ||
Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both so... | |||
T71903 | Meclocycline | ||
Meclocycline is a tetracycline antibiotic with broad antimicrobial activity. Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the hunting... | |||
T61991 | HTT-D3 | ||
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 can lead to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and has research value in Huntin... | |||
T74881 | FITC-labeled Tominersen | ||
FITC-labeled Tominersen is Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT p... | |||
T73289 | MHTT-IN-1 | ||
mHTT-IN-1 (Example 1) is a potent inhibitor of the mutant huntingtin protein (mHTT), which is toxic and primarily responsible for Huntington's disease (HD), an inherited autosomal dominant neurodegenerative disorder. Thi... | |||
T38279 | C2-8 | C2-8 | |
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola... | |||
T83945 | XIE62-1004 | ||
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso... | |||
T79717 | MHTT-IN-2 | Huntingtin | |
mHTT-IN-2 (compound 27) is a potent inhibitor of mutant huntingtin protein (mHTT), with an EC50 value of 0.066 μM. It specifically modulates the splicing of HTT RNA exons [49-50], acting as a splicing regulator for the H... |