hif — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T67767	HIF-1 inhibitor-4	HIF-1 inhibitor-4	HIF
	HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.		HIF
T11561	HIF-2α-IN-2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).		HIF/HIF Prolyl-Hydroxylase , HIF
T15482	HIF-2α-IN-1		HIF
	HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.		HIF
T50099	HIF-2α-IN-4		Others , HIF/HIF Prolyl-Hydroxylase
	HIF-2a translation inhibitor is a compound used as a molecular building block.		Others , HIF/HIF Prolyl-Hydroxylase
T67831	HIF-2α agonist 2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reh...		HIF/HIF Prolyl-Hydroxylase , HIF
T11562	HIF-2α-IN-3		HIF
	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.		HIF
T3180	JNJ-42041935	HIF-PHD Inhibitor II	HIF/HIF Prolyl-Hydroxylase
	JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.		HIF/HIF Prolyl-Hydroxylase
T61349	HIF-1α-IN-2		HIF
	HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration.		HIF
T75098	HIF-PHD-IN-3		Reactive Oxygen Species
	HIF-PHD-IN-3 is a potent hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.		Reactive Oxygen Species
T25502	HIF-IN-33	HIF IN 33,HIF Pathway Inhibitor 33
	HIF-IN-33 is an inhibitor of HIF pathway.
T3494	LW6	HIF-1α inhibitor,CAY10585,LW8	Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
	LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T36711	FM19G11	FM19G11,HIF-1alpha/2alpha Inhibitor	HIF
	FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).		HIF
TP1533	HIF-1 alpha (556-574)	HIF-1 alpha 556-574
	HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1subunit is stabilized i...
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therap...
T36290	HIF-1 inhibitor-1
	HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi[1]. [1]. Liu M, et al. Discovery of Novel Aryl Carboxamide Deri...
TP1546	HIF-1 alpha (556-574) TFA (1201633-99-9 free base)	HIF-1 alpha (556-574) TFA
	This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in resp...
T60413	HIF-IN-1		HIF
	HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.		HIF
T61367	HIF-2α-IN-6
	HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].
T72997	HIF-2α-IN-7
	HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor. HIF-2α-IN-7 can inhibit HIF-2α with an EC 50 value of 6 nM. HIF-2α-IN-7 can be used for the research of various types of diseases including cancer , liver ...
T60524	HIF-1α-IN-4
	HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1].