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Search Result

Search Results for " grk "

13

Compounds

Cat No. Product Name Synonyms Targets
T35723 GRK-IN-1
4-Amino-5-(bromomethyl)-2-methylpyrimidine is a heterocyclic building block.1,2 It has been used in the synthesis of vitamin B1 analogs and thiaminephosphoric acid esters. |1. Abblard, J., Cronenberger, L., and Pacheco, ...
T9609 GRK5-IN-2 GRK
GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and/or release of insulin and is useful for the metabolic disease research.
TP2025 GRK2i
GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
T25464 GRK2 Inhibitor βARK1 Inhibitor
GRK2 Inhibitor is an inhibitor of β-Adrenergic Receptor Kinase 1 (β ARK1).
T13714L GRK2-IN-1 hydrochloride (2055990-90-2 free base) GRK2-IN-1 hydrochloride GRK
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
T61556 GRK6-IN-2 GRK
GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.
T79913 GRK2 Inhibitor 2
GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293 cells. It is utilized in congestive heart failure (HF) resear...
T63203 GRK5-IN-4
GRK5-IN-4 is a selective, potent, covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor (IC50: 1.1 μM).GRK5-IN-4 is 90 times more selective for GRK5 than GRK2.GRK5-IN-4 can be used to study heart failure.
T62518 GRK6-IN-1
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) (IC50: 120 nM). GRK6-IN-1 has the potential to be studied in multiple myeloma.
T62599 GRK5-IN-3
GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).
T75935 GRK2i TFA
GRK2i TFA, a GRK2 inhibitory polypeptide, specifically targets and inhibits the activation of GRK2 by Gβγ. It mimics the Gβγ-binding domain, functioning as a cellular antagonist of Gβγ [1].
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T24106 GSK2163632A GSK-2163632-A,GSK 2163632 A
GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.
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