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GRK2-IN-1 hydrochloride (2055990-90-2 free base)

Catalog No. T13714L CAS T13714L

Synonyms: GRK2-IN-1 hydrochloride

GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).

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GRK2-IN-1 hydrochloride (2055990-90-2 free base) Chemical Structure

GRK2-IN-1 hydrochloride (2055990-90-2 free base), CAS T13714L

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 108.00
2 mg	Inquiry	$ 179.00
5 mg	Inquiry	$ 311.00
10 mg	Inquiry	$ 486.00
25 mg	Inquiry	$ 873.00
50 mg	Inquiry	$ 1,454.00
100 mg	Inquiry	$ 1,981.00
200 mg	Inquiry	Inquiry
500 mg	Inquiry	Inquiry
1 mL * 10 mM (in DMSO)	Inquiry	$ 334.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).
Targets&IC50	GRK2:30 nM, GRK5:7.1 μM
In vitro	GRKs-IN-1 hydrochloride (Compound 14as) is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine.

Synonyms	GRK2-IN-1 hydrochloride
Molecular Weight	488.94
Formula	C24H26ClFN4O4
CAS No.	T13714L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (511.31 mM), Sonification is recommended.

References and Literature

1. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.

Related Products

Related compounds with same targets

GRK6-IN-2 GSK270822A GSK299115A GSK180736A CCG258208 CMPD101 GRK5-IN-2 Paroxetine hydrochloride

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Keywords

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