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Search Results for " gabaa "

20

Compounds

Cat No. Product Name Synonyms Targets
T11349 GABAA receptor agent 1 GABA Receptor
GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.
T61668 GABAA receptor agent 5
GABAA Receptor Agent 5 (compound 018) serves as a potent γ-GABAAR antagonist, possessing a Ki of 0.020 μM. This compound exhibits γ-GABAAR antagonist properties, yet it demonstrates low cellular membrane permeability [1]...
T60842 GABAA receptor agonist 1
GABAA receptor agonist 1 (compound 3e) is a potent agonist of GABAA receptor that binds at the GABA binding site of GABAA receptor to produce GABAergic effects. GABAA receptor agonist 1 has anti-depression activities in ...
T60481 GABAA receptor agent 4
GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR with Ki of 0.18 µM. GABAA receptor agent 4 has immunomodulatory potential which was shown to efficiently rescue the inhibition of T cell proliferati...
T60817 GABAA receptor agent 6
GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with low cellular membrane permeability (Ki = 0.56 μM) [1].
T61625 GABAA receptor agonist 2
GABAA receptor agonist 2 (compound 4c) is a highly potent GABAA receptor agonist which exhibits anti-depressive properties in classical mouse models of depression, such as the FST and TST. By binding to the GABA binding ...
T61052 GABAA receptor agent 7
GABAA receptor agent 7 (compoud 5c) has anticonvulsant activity both in vitro and in vivo with low neurotoxicity which can be used in epilepsy research. GABAA receptor agent 7 is a potent positive modulator of GABAA rece...
T60826 GABAA receptor agent 8
GABAA receptor agent 8 (compoud 5e) has the potential in epilepsy research. GABAA receptor agent 8 is a potent positive modulator of GABAA receptor with anticonvulsant activity both in vitro and in vivo as well as low ne...
T62885 GABAA receptor modulator-2
GABAA receptor modulator-2 (Compound 20) is a selective, orally active α5-GABAAR negative conformation modulator (Ki: 4.1 nM). gABAA receptor modulator-2 exhibits high metabolic stability and a good central nervous syste...
T62426 GABAA receptor agent 2 TFA
GABAA receptor agent 2 TFA is a potent, high-affinity GABAA receptor antagonist with an IC50 of 24 nM (human α1β2γ2GABAA-expressing tsA201 cells) and a Ki of 28 nM (rat GABAA receptor). GABAA receptor agent 2 TFA has no ...
T4S1999 Valepotriate Valtrate Apoptosis , HIV Protease
Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agen...
T8887 2'MeO6MF GABA Receptor
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...
T5S1882 Songorine Napellonine,Zongorine,Bullatine G Others , GABA Receptor
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
T2S1464 Thiocolchicoside Thiocolchicine 2-glucoside analog,Coltramyl Others , GABA Receptor
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...
T7165 Basmisanil RG1662,RO5186582 GABA Receptor
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...
T11277 FG 7142 ZK 39106,LSU-65 GABA Receptor
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...
T7794 Zuranolone GABA Receptor
Zuranolone is an agonist of GABAA receptor.
T17144 TPA 023 GABA Receptor
TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).
T23339 SCS GABA Receptor
SCS is a GABAA receptor antagonist.
T7622 Gabazine SR95531 GABA Receptor
Gabazine (SR95531) is an antagonist of GABAA receptors (Ki : 74-150 nM)
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TargetMol