ecm — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16695	Pyrintegrin		Integrin
	Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances cell-extracellular matrix adhesion-mediated integrin signal...		Integrin
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T60021	ecMetAP-IN-1		Others
	ecMetAP-IN-1 can be used as a QSAR model to study methionine aminopeptidase inhibitor as an anticancer agent using multiple linear regression.		Others
TN1833	Karacoline		NF-κB
	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.		NF-κB
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T40795	BNTA		Reactive Oxygen Species
	BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxid...		Reactive Oxygen Species
TL0001	Dencichine	L-Dencichin,ODAP,Dencichin	Others , HIF/HIF Prolyl-Hydroxylase
	Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...		Others , HIF/HIF Prolyl-Hydroxylase
T15613	JHU-083		Others
	JHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.		Others
T81728	Myristoyl tetrapeptide Ala-Ala-Pro-Val
	Myristoyl tetrapeptide Ala-Ala-Pro-Val is a bioactive peptide that stimulates the expression of extracellular matrix (ECM) proteins and inhibits the expression of metalloproteinases (MMPs).
T69294	UK‑396082
	UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research...
T39168	Epsilon-(gamma-glutamyl)-lysine	Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH
	Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicat...
T73760	Epsilon-(gamma-glutamyl)-lysine TFA
	Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA, an N(6)-acyl-L-lysine derivative, plays a crucial role in the formation of epsilon-(gamma-glutamyl)lysine crosslinks within the extracellular matrix (ECM) compone...
T71471	Chrysotobibenzyl
	Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellula...
T76007	RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) TFA functions as an inhibitor of integrin-ligand interactions, competitively blocking α5β1's interaction with the extracellular matrix (ECM). It induces apoptosis by triggering conformational changes...
T78018	Plasminogen
	Plasminogen is a zymogen secreted as a precursor protein that, when cleaved by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA), is converted into plasmin. Plasmin is a protease with broad spec...
TP1343	RGD Trifluoroacetate
	RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.RGD Trifluoroacetate is the most eff...