do1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7857	DO1	Disperse Orange 1	Others
	DO1 (Disperse Orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations		Others
T11901	IDO1-IN-5		IDO , Indoleamine 2,3-Dioxygenase (IDO)
	IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.		IDO , Indoleamine 2,3-Dioxygenase (IDO)
T20513	IDO1-IN-1	IDO1 inhibitor 1,2 HzBTZ,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO
	IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.		IDO
T61789	IDO1-IN-14
	IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeL...
T63034	IDO1-IN-13
	IDO1-IN-13 (compound 27a) is a potent inhibitor of IDO1 (IC50: 61.6 nM). Ido1-in-13 inhibits cell IDO1 with an EC50 value of 30 nM for HeLa. In SK-OV-3 xenograft tumor tissue, IDO1-IN-13 reduced kyn/trp ratio by 51%.
T63222	IDO1/2-IN-1
	IDO1/2-IN-1 is the first potent, orally active dual IDO1/IDO2 inhibitor, exhibiting antitumor effects with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively.
T78687	IDO1-IN-21		Indoleamine 2,3-Dioxygenase (IDO)
	IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].		Indoleamine 2,3-Dioxygenase (IDO)
T61944	IDO1-IN-15
	IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.
T12668	(Rac)-IDO1-IN-5		Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature he...		Others
T61385	IDO1/TDO-IN-1
	IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhi...
T62638	IDO1-IN-18
	IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.
T11625	IDO1 and HDAC1 Inhibitor		Others
	IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).		Others
T39946	IDO1-IN-12	IDO1-IN-12
	IDO1-IN-12 is a potent and orally available IDO1 inhibitor.
T78795	IDO1/TDO-IN-6		Indoleamine 2,3-Dioxygenase (IDO)
	IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demonstrates Ki values of 1.9 μM for IDO1 and 3.1 μM for TDO, m...		Indoleamine 2,3-Dioxygenase (IDO)
T73111	IDO1-IN-17
	IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .
T11624	IDO1-IN-2		IDO
	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.		IDO
T60318	IDO1/TDO-IN-4
	IDO1/TDO-IN-4 displays potent inhibition of both IDO1 (IC50 = 3.53 μM) and TDO (IC50 = 1.15 μM) and has an acceptable safety profile and pharmacokinetic properties. IDO1/TDO-IN-4 forms a hydrogen bond with IDO1, and π π ...
T78975	IDO1-IN-22		Indoleamine 2,3-Dioxygenase (IDO)
	IDO1-IN-22 (Compound 3) is an inhibitor of IDO1, demonstrating potent activity with biochemical hIDO1 IC50 of 67.4 nM and HeLa hIDO1 IC50 of 17.6 nM. It exhibits excellent antitumor efficacy in an LLC xenograft model and...		Indoleamine 2,3-Dioxygenase (IDO)
T63082	IDO1-IN-19
	IDO1-IN-19 (Compound 17) is a potent inhibitor of IDO1 and has potential for cancer disease research.
T63780	IDO1-IN-16
	IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).