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IDO1-IN-2

Catalog No. T11624 CAS 2346614-58-0

IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.

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IDO1-IN-2, CAS 2346614-58-0

Pack Size	Availability	Price/USD	Quantity
25 mg	6-8 weeks	$ 1,520.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
Targets&IC50	IDO1:81 nM
In vitro	IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood.IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM.
In vivo	IDO1-IN-2 exhibits pharmacokinetic properties with a half-life (t1/2) of 3.7 hours, a clearance/bioavailable unbound clearance (CL/CLu) of 15/319 mL/min/kg, and bioavailability (F) of 63% in rats. In dogs, its half-life extends to 6 hours, with a CL/CLu of 6/88 mL/min/kg, and a bioavailability of 67%. Furthermore, IDO1-IN-2, administered at a dose of 100 mg/kg twice daily, effectively enhances therapeutic outcomes when used alongside anti-PD-1 monoclonal antibodies (mAb) in a mouse EMT6 tumor syngeneic model, demonstrating significant synergy in efficacy.

Molecular Weight	364.33
Formula	C15H17FN6O4
CAS No.	2346614-58-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536.

Related Products

Related compounds with same targets

IDO1-IN-1 Linrodostat IDO-IN-9 IDO1-IN-5 IACS-8968 R-enantiomer GNF-PF-3777 IDO-IN-11 BMS-986242

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IDO1-IN-2 2346614-58-0 Metabolism IDO IDO1 IN 2 IDO1IN2 IDO-1-IN-2 inhibitor inhibit

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