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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7194 | CM-272 | Apoptosis , DNA Methyltransferase , Histone Methyltransferase | |
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. | |||
T16269 | Nanaomycin A | DNA Methyltransferase , Dehydrogenase , Parasite | |
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM). | |||
T1904 | SGI-1027 | DNA Methyltransferase Inhibitor II,SGI1027 | Apoptosis , DNA Methyltransferase |
SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively. | |||
T15169 | DS-437 | Others | |
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3. | |||
T11185 | EML741 | Histone Methyltransferase | |
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase... | |||
T81432 | PNMT-IN-1 | ||
PNMT-IN-1 (inhibitor 4) is a selective second generation inhibitor [1] of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 1.2 nM and an IC50 value of 81 nM. Additionally, it disrupts the activity ... | |||
T10840L | CM-579 | DNA Methyltransferase , Histone Methyltransferase | |
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells. | |||
T10840 | CM-579 trihydrochloride (1846570-40-8 free base) | CM-579 trihydrochloride | DNA Methyltransferase |
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells. |