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Search Results for " dnmt3b "

8

Compounds

Cat No. Product Name Synonyms Targets
T7194 CM-272 Apoptosis , DNA Methyltransferase , Histone Methyltransferase
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T16269 Nanaomycin A DNA Methyltransferase , Dehydrogenase , Parasite
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
T1904 SGI-1027 DNA Methyltransferase Inhibitor II,SGI1027 Apoptosis , DNA Methyltransferase
SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.
T15169 DS-437 Others
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
T11185 EML741 Histone Methyltransferase
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase...
T81432 PNMT-IN-1
PNMT-IN-1 (inhibitor 4) is a selective second generation inhibitor [1] of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 1.2 nM and an IC50 value of 81 nM. Additionally, it disrupts the activity ...
T10840L CM-579 DNA Methyltransferase , Histone Methyltransferase
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
T10840 CM-579 trihydrochloride (1846570-40-8 free base) CM-579 trihydrochloride DNA Methyltransferase
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.
TargetMol